Ponències/Comunicacions de congressoshttp://hdl.handle.net/2117/36102024-03-29T06:43:37Z2024-03-29T06:43:37ZNanoparticles made of poly(gama-glutamic acid) derivatives for drug delivery systemsDorost, PorochistaMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonGarcía Álvarez, Montserrathttp://hdl.handle.net/2117/3879072023-05-26T08:40:15Z2023-05-26T08:34:06ZNanoparticles made of poly(gama-glutamic acid) derivatives for drug delivery systems
Dorost, Porochista; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; García Álvarez, Montserrat
One of the treatments for cancer is chemotherapy but most anticancer drugs have a low therapeutic index, which causes toxicity complications in the healthy tissues [1]. To minimize these complications and improve the effect of the existing drugs, drug delivery by nanoparticles have drawn more attention as they are easy to produce and can also be prepared through biocompatible polymers [2]. Here, we report the preparation of polymer nanoparticles derived from esters of poly(¿-glutamic acid) which could be able to encapsulate hydrophobic drugs that can be used as drug delivery systems (DDS) for the treatment of different tumours. In this work, PGGA has been modified in order to improve its solubility in organic solvents and its processing capacity of this water-soluble polymer. Due to the fact that most of the anticancer drugs are lipophilic, the hydrophobic modification of PGGA will enhance the drug encapsulation.
2023-05-26T08:34:06ZDorost, PorochistaMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonGarcía Álvarez, MontserratOne of the treatments for cancer is chemotherapy but most anticancer drugs have a low therapeutic index, which causes toxicity complications in the healthy tissues [1]. To minimize these complications and improve the effect of the existing drugs, drug delivery by nanoparticles have drawn more attention as they are easy to produce and can also be prepared through biocompatible polymers [2]. Here, we report the preparation of polymer nanoparticles derived from esters of poly(¿-glutamic acid) which could be able to encapsulate hydrophobic drugs that can be used as drug delivery systems (DDS) for the treatment of different tumours. In this work, PGGA has been modified in order to improve its solubility in organic solvents and its processing capacity of this water-soluble polymer. Due to the fact that most of the anticancer drugs are lipophilic, the hydrophobic modification of PGGA will enhance the drug encapsulation.Fluorine-free waterborne textile finishing agents for anti-stain and solvent-water separation based on low surface energy (co)poly(methacrylate)sLacruz, AmadoSalvador, MireiaBlanco, MirenVidal, KarmeleMartínez de Ilarduya Sáez de Asteasu, Domingo Antxonhttp://hdl.handle.net/2117/3834602023-02-16T08:30:22Z2023-02-16T08:20:57ZFluorine-free waterborne textile finishing agents for anti-stain and solvent-water separation based on low surface energy (co)poly(methacrylate)s
Lacruz, Amado; Salvador, Mireia; Blanco, Miren; Vidal, Karmele; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon
Fabric functionalization to obtain omniphobic textiles is an increasing trend in our current society [1]. Fluorochemicals dominate the water and oil-repellent textile finishing market because of their excellent performance. However, fluorinated chemicals release harmful substances giving rise to serious damage to ecosystems worldwide [2]. In this work, a series of fluorinefree, low surface energy and partially bio-based (co)polymethacrylates based on 3- [Tris(trimethylsilyloxy)silyl]propyl methacrylate (M3T) and stearyl methacrylate (SMA) (Figure 1) have been successfully synthesized by emulsion polymerization and characterized by different spectroscopic and thermal methods.
2023-02-16T08:20:57ZLacruz, AmadoSalvador, MireiaBlanco, MirenVidal, KarmeleMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonFabric functionalization to obtain omniphobic textiles is an increasing trend in our current society [1]. Fluorochemicals dominate the water and oil-repellent textile finishing market because of their excellent performance. However, fluorinated chemicals release harmful substances giving rise to serious damage to ecosystems worldwide [2]. In this work, a series of fluorinefree, low surface energy and partially bio-based (co)polymethacrylates based on 3- [Tris(trimethylsilyloxy)silyl]propyl methacrylate (M3T) and stearyl methacrylate (SMA) (Figure 1) have been successfully synthesized by emulsion polymerization and characterized by different spectroscopic and thermal methods.Poly(ether-ester-peptide) triblock copolymers: Synthesis and self-assembly behaviorTinajero, ErnestoMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, Sebastiánhttp://hdl.handle.net/2117/1353722022-06-12T09:23:05Z2019-06-26T08:25:25ZPoly(ether-ester-peptide) triblock copolymers: Synthesis and self-assembly behavior
Tinajero, Ernesto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián
Triblock/grafted poly(ether-ester-peptide) copolymers made or PEG, poly(globablide) and poly(L-phenylalanine) were synthesized by sequential ROP starting from diaminated PEG as first initiator. The aromatic functionality of L-phenylalanine inserted on the globalide units was utilized to impart the amphiphilicity required to drive their self-assembly in water and to provide aromaticity of potential value for the efficient loading of aromatic drugs. Depending of the method used for preparation, nanoparticles possessing diameters between 25 and 600 nm were obtained by self-assembling in aqueous medium.
2019-06-26T08:25:25ZTinajero, ErnestoMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, SebastiánTriblock/grafted poly(ether-ester-peptide) copolymers made or PEG, poly(globablide) and poly(L-phenylalanine) were synthesized by sequential ROP starting from diaminated PEG as first initiator. The aromatic functionality of L-phenylalanine inserted on the globalide units was utilized to impart the amphiphilicity required to drive their self-assembly in water and to provide aromaticity of potential value for the efficient loading of aromatic drugs. Depending of the method used for preparation, nanoparticles possessing diameters between 25 and 600 nm were obtained by self-assembling in aqueous medium.Nanostructured amphiphilic systems based on hyaluronic acid ionic complexesGamarra Montes, AnaAlla Bedahnane, AbdelilahMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonCasas Becerra, María TeresaMuñoz Guerra, Sebastiánhttp://hdl.handle.net/2117/910962022-03-13T02:53:28Z2016-10-26T10:10:17ZNanostructured amphiphilic systems based on hyaluronic acid ionic complexes
Gamarra Montes, Ana; Alla Bedahnane, Abdelilah; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Casas Becerra, María Teresa; Muñoz Guerra, Sebastián
In this communication we wish to report on HyA ionic complexes prepared by coupling with a) choline-based surfactants (nACh·HyA complexes), and b) alkylphosphonium surfactants (nATMP·HyA complexes) with n being the number of carbons of the alkanoyl or alkyl side chain. nACh surfactants are synthesized from choline and fatty acids, and distinguished because they are fully biobased and biocompatible. The nATMP surfactants have been scarcely studied as counterions of polyacids in spite of being more stable to heat and less harmful than their alkylammonium analogs.
2016-10-26T10:10:17ZGamarra Montes, AnaAlla Bedahnane, AbdelilahMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonCasas Becerra, María TeresaMuñoz Guerra, SebastiánIn this communication we wish to report on HyA ionic complexes prepared by coupling with a) choline-based surfactants (nACh·HyA complexes), and b) alkylphosphonium surfactants (nATMP·HyA complexes) with n being the number of carbons of the alkanoyl or alkyl side chain. nACh surfactants are synthesized from choline and fatty acids, and distinguished because they are fully biobased and biocompatible. The nATMP surfactants have been scarcely studied as counterions of polyacids in spite of being more stable to heat and less harmful than their alkylammonium analogs.Poly(butylene 2,5-furan dicarboxylate-co-butylene succinate) via ring opening polymerizationMorales Huerta, Juan CarlosCiulik, ClaudioMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, Sebastiánhttp://hdl.handle.net/2117/910952020-07-23T21:15:13Z2016-10-26T09:46:02ZPoly(butylene 2,5-furan dicarboxylate-co-butylene succinate) via ring opening polymerization
Morales Huerta, Juan Carlos; Ciulik, Claudio; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián
In this communication we wish to report on the synthesis of PBFxSy copolyesters by ring opening polymerization (ROP) using either organometallic catalysts or enzymes. The ROP of macrocyclic oligomers (MCOs) has been demonstrated to offer significant advantages over the traditional polycondensation method. The synthesis of MCOs of butylene succinate c(BS)n is known from long whereas MCOs of butylene 2,5-furandicarboxylate (c(BF)n) have not been reported until very recently. In this work, the synthesis of c(BF)n and c(BS)n has been performed using high dilution condensation (HDC) and enzymatic cyclization, respectively. Mixtures of dimer to tetramer and dimer to nonamer were obtained for c(BF)n and c(BS)n respectively.
2016-10-26T09:46:02ZMorales Huerta, Juan CarlosCiulik, ClaudioMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, SebastiánIn this communication we wish to report on the synthesis of PBFxSy copolyesters by ring opening polymerization (ROP) using either organometallic catalysts or enzymes. The ROP of macrocyclic oligomers (MCOs) has been demonstrated to offer significant advantages over the traditional polycondensation method. The synthesis of MCOs of butylene succinate c(BS)n is known from long whereas MCOs of butylene 2,5-furandicarboxylate (c(BF)n) have not been reported until very recently. In this work, the synthesis of c(BF)n and c(BS)n has been performed using high dilution condensation (HDC) and enzymatic cyclization, respectively. Mixtures of dimer to tetramer and dimer to nonamer were obtained for c(BF)n and c(BS)n respectively.Bio-based aromatic polyesters and copolyesters by ring opening polymerizationMorales Huerta, Juan CarlosMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, Sebastiánhttp://hdl.handle.net/2117/910942020-07-23T20:14:57Z2016-10-26T09:40:28ZBio-based aromatic polyesters and copolyesters by ring opening polymerization
Morales Huerta, Juan Carlos; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián
In this work, the synthesis of both c(BF)n and c(BT)n has been performed using the high dilution cyclization technique and these cycles have been then used for the preparation of the homopolyesters PBF and PBT, as well as of a series of poly(butylene 2,5-furandicarboxylate-co-terephthalate) (coPBFxTy) with a wide range of compositions (Fig. 1). Results are compared with those obtained from similar copolyesters prepared by melt polycondensation, which have been recently reported
2016-10-26T09:40:28ZMorales Huerta, Juan CarlosMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, SebastiánIn this work, the synthesis of both c(BF)n and c(BT)n has been performed using the high dilution cyclization technique and these cycles have been then used for the preparation of the homopolyesters PBF and PBT, as well as of a series of poly(butylene 2,5-furandicarboxylate-co-terephthalate) (coPBFxTy) with a wide range of compositions (Fig. 1). Results are compared with those obtained from similar copolyesters prepared by melt polycondensation, which have been recently reportedRing opening polymerization of macrolactones using amines as initiatorsTinajero, ErnestoLavilla, CristinaMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, Sebastiánhttp://hdl.handle.net/2117/910922022-06-12T01:16:55Z2016-10-26T09:31:17ZRing opening polymerization of macrolactones using amines as initiators
Tinajero, Ernesto; Lavilla, Cristina; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián
The ring opening polymerization (ROP) of these macrolactones mediated by alcohols as initiators and organic and metal-based catalysts has been reported before with satisfactory results [4,5]. In the present work, the polymerization of these macrolactones has been studied using amines as initiators. The ROP of both PDL and 6HDL was carried out in bulk at 100 oC using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as organocatalyst. Distinct types of amines were tested as initiators for the ROP of these macrolactones. The copolymerization reaction was also studied by ROP of PDL and 6HDL with an oligo-polyethylene glycol bis(3-aminopropyl) terminated and an amino-ended homopolypeptide (poly(¿-benzyl a,Lglutamate) as initiator.
2016-10-26T09:31:17ZTinajero, ErnestoLavilla, CristinaMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, SebastiánThe ring opening polymerization (ROP) of these macrolactones mediated by alcohols as initiators and organic and metal-based catalysts has been reported before with satisfactory results [4,5]. In the present work, the polymerization of these macrolactones has been studied using amines as initiators. The ROP of both PDL and 6HDL was carried out in bulk at 100 oC using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as organocatalyst. Distinct types of amines were tested as initiators for the ROP of these macrolactones. The copolymerization reaction was also studied by ROP of PDL and 6HDL with an oligo-polyethylene glycol bis(3-aminopropyl) terminated and an amino-ended homopolypeptide (poly(¿-benzyl a,Lglutamate) as initiator.Bio-based aliphatic polyesters from aliphatic diacids and bicyclic alditols: A comparative studyZakharova, ElenaMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, Sebastiánhttp://hdl.handle.net/2117/910892020-07-23T20:24:45Z2016-10-26T09:13:42ZBio-based aliphatic polyesters from aliphatic diacids and bicyclic alditols: A comparative study
Zakharova, Elena; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián
In this work we have prepared and compared the thermal and mechanical properties of aliphatic polyesters made from aliphatic diacids with different polymethylene chain lengths (2, 4, 6, 8) and three bicyclic sugar derived diols namely, dianhydro-1,4:3,6-D-glucitol (also known as isosorbide, Is), and two bicyclic diazetalized hexitols, 2,4:3,5-di-O-methylene- D-mannitol (Manx-diol) and -D-glucitol (Glux-diol) derived from D-mannose and D-glucose respectively (Fig. 1)
2016-10-26T09:13:42ZZakharova, ElenaMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonMuñoz Guerra, SebastiánIn this work we have prepared and compared the thermal and mechanical properties of aliphatic polyesters made from aliphatic diacids with different polymethylene chain lengths (2, 4, 6, 8) and three bicyclic sugar derived diols namely, dianhydro-1,4:3,6-D-glucitol (also known as isosorbide, Is), and two bicyclic diazetalized hexitols, 2,4:3,5-di-O-methylene- D-mannitol (Manx-diol) and -D-glucitol (Glux-diol) derived from D-mannose and D-glucose respectively (Fig. 1)Copoliésteres alifáticos derivados del ácido galactárico diacetalizadoLavilla Aguilar, CristinaAlla Bedahnane, AbdelilahMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonBenito, ElenaGarcía Martín, Maria de GraciaGalbis Pérez, Juan AntonioMuñoz Guerra, Sebastiánhttp://hdl.handle.net/2117/183742020-07-23T20:45:19Z2013-03-18T15:25:18ZCopoliésteres alifáticos derivados del ácido galactárico diacetalizado
Lavilla Aguilar, Cristina; Alla Bedahnane, Abdelilah; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Benito, Elena; García Martín, Maria de Gracia; Galbis Pérez, Juan Antonio; Muñoz Guerra, Sebastián
2013-03-18T15:25:18ZLavilla Aguilar, CristinaAlla Bedahnane, AbdelilahMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonBenito, ElenaGarcía Martín, Maria de GraciaGalbis Pérez, Juan AntonioMuñoz Guerra, SebastiánPoly(ethylene terephthalate) terpolyesters containing 1,4-cyclohexanedimethanol and isosorbideQuintana Vicente, RobertMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonAlla Bedahnane, AbdelilahMuñoz Guerra, Sebastiánhttp://hdl.handle.net/2117/106842020-07-23T22:09:57Z2010-12-20T13:34:18ZPoly(ethylene terephthalate) terpolyesters containing 1,4-cyclohexanedimethanol and isosorbide
Quintana Vicente, Robert; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Alla Bedahnane, Abdelilah; Muñoz Guerra, Sebastián
New PET derived terpolyesters have been synthesized y incorporation of CHDM and the biobased monomer isosorbide. It was observed that this incorporation repressed the crystallinity, increased the Tg improved the processability.
2010-12-20T13:34:18ZQuintana Vicente, RobertMartínez de Ilarduya Sáez de Asteasu, Domingo AntxonAlla Bedahnane, AbdelilahMuñoz Guerra, SebastiánNew PET derived terpolyesters have been synthesized y incorporation of CHDM and the biobased monomer isosorbide. It was observed that this incorporation repressed the crystallinity, increased the Tg improved the processability.