Machine learning algorithms and the increasing availability of data have radically changed the way how decisions are made in today’s Industry. A wide range of algorithms are being used to monitor industrial processes and predict process variables that are difficult to be measured. Maintenance operations are mandatory to tackle in all industrial equipment. It is well known that a huge amount of money is invested in operational and maintenance actions in industrial gas turbines (IGTs). In this paper, two variations of autoencoders were used to analyse the performance of an IGT after major maintenance. The data used to analyse IGT conditions were ambient factors, and measurements were performed using several sensors located along the compressor. The condition assessment of the industrial gas turbine compressor revealed significant changes in its operation point after major maintenance; thus, this indicates the need to update the internal operating models to suit the new operational mode as well as the effectiveness of autoencoder-based models in feature extraction. Even though the processing performance was not compromised, the results showed how this autoencoder approach can help to define an indicator of the compressor behaviour in long-term performance.