An application of a meshless numerical method on a macrosegregation benchmark case is developed in the present paper. The test case is solidification in 2D rectangular cavity, filled with liquid metal and chilled from both sides. This is a highly non-linear problem due to a strong coupling of the macroscopic transport equations with the microsegregation model. The main result is the macrosegregation pattern of the solidified metal Al4.5wt%Cu alloy is used for evaluation of the problem. The model uses diffuse approximate meshless method with the second-order polynomial basis for spatial integration and explicit time-stepping. Simulations are performed on uniform and non-uniform computational node arrangements and compared to each other. The results on uniform and non-uniform node arrangements show a very good matching with the finite volume method results and results based on radial basis function collocation method. This shows that diffuse approximate method based on non-uniform node arrangements can be used for solving macrosegregation problems.