This study investigates the role of work–family conflict (WFC), family–work conflict (FWC), and two dimensions of burnout (emotional exhaustion and cynicism) in mediating the relationships between work demands and job satisfaction, life satisfaction, and turnover intention across a Middle Eastern country and a European country. The study uses two samples including 263 full-time employees from both countries. The quantitative analysis using structural equation modeling (SEM) revealed that higher levels of work–family conflict (WFC), and family–work conflict (FWC) were associated with lower levels of job satisfaction and life satisfaction. Additionally, burnout showed negative effects on job and life satisfaction, and a positive relationship with turnover intentions across nations. Differences were also found between country samples, with employed women from the Middle Eastern country experiencing higher dual-role conflict and lower satisfaction.