Enterprise systems are increasingly composed of (and even functioning as) components in a dynamic, digital ecosystem. On the one hand, this new situation requires flexible, spontaneous and opportunistic collaboration activities to be identified and established among (electronic) business parties. On the other, it demands engineering methods that are able to integrate new functionalities and behaviours into running systems composed by active, distributed, interdependent processes. Here we present a multi-level architecture that combines organisational and coordination theories with model driven development, for the implementation, deployment and management of dynamic, flexible and robust service-oriented business applications, combined with a service layer that accommodates semantic service description, fine-grained semantic service discovery and the dynamic adaptation of services to meet changing circumstances