The paper presents an experimental program on the characterisation of the mechanical behaviour of perforated brick masonry (PBM) under uniaxial compression. The study is aimed to provide a better understanding on the compressive strength and elastic behaviour of a kind of masonry hardly dealt with in the literature. The mechanical response of the investigated masonry shows actually two complexities, linked respectively to the perforated nature of the bricks and the asymmetric cross-section of the units. The latter feature is particularly recurrent in exposed brickwork composed of perforated bricks, whenever one of the face shells has a larger thickness than the other one. For this purpose, an experimental campaign was carried out on units and PBM subjected to uniaxial compressive loading. The mechanical response of PBM is investigated to accurately determine the masonry Young’s modulus and the compressive strength. Measurements obtained with conventional sensors are compared with those derived from the Digital Image Correlation (DIC) technique. Lastly, the experimental findings in terms of compressive strength and Young’s modulus are cross-referenced with the estimations derived from empirical criteria available in Eurocode 6 and ACI 530.1–02.