There is broad recognition within the scientific community that the ongoing deluge of scientific data is fundamentally transforming almost all areas of academic research. A wide variety of researchers —from scientists and engineers to social scientists and humanities researchers – now require tools, technologies, and platforms that seamlessly integrate into standard scientific methodologies and processes. “The Fourth Paradigm” refers to the data management techniques and the computational systems needed to manipulate, analyze, visualize, and manage large amounts of research data. This talk will illustrate the challenges researchers will face, the opportunities these changes will afford, and the resulting implications for data-intensive researchers. In addition, the talk will discuss the issues of open access, open data and open science and research reproducibility.