This study analyzes the atmospheric variability that caused the largest floods affecting the town of Tortosa, Spain, in the mouth of the Ebro River (northeast Iberian Peninsula). The Tortosa flood database and flood marks in the nearby town of Xerta are used to define the more relevant flooding episodes (discharges >2900 m3 s-1) of the 1600–2005 period. We explore the atmospheric variability based on low-frequency patterns and synoptic types applying a multivariable analysis to grids at sea level pressure and geopotential at 500 hPa provided by the twentieth-century V3 Reanalysis Project for the instrumental period (since 1836). Output from the Last Millennium Ensemble Project was used to analyze the sea level pressure over the pre-instrumental period (before 1836). Our analysis includes 33 flood episodes.