This paper presents a complete methodology for the development of an integrated software architecture, which can achieve a closed-loop application between the integrated real-time control (RTC) and a virtual reality simulation for the urban drainage system (UDS). Quality measurements are considered during the simulation and optimization process. Model predictive control (MPC) and rule-based control (RBC) are the two main RTC methods embedded in this architecture. The proposed integration environment allows the different software components to efficiently and effectively communicate and work in a system-wide way, as well as to execute all the necessary steps regarding input parameter management, scenario configuration and results extraction. The proposed approaches are implemented into a pilot based on the Badalona UDS (Spain). Results from different scenarios with individual control approaches and rain episodes are evaluated and discussed.