This paper proposes an approach for the joint state and fault estimation for a class of uncertain nonlinear systems with simultaneous unknown input and actuator faults. This is achieved by designing an unknown input observer combined with a set-membership estimation in the presence of disturbances and measurement noise. The observer is designed using quadratic boundedness approach that is used to overbound the estimation error. Sufficient conditions for the existence and stability of the proposed state and actuator fault estimator are expressed in the form of linear matrix inequalities (LMIs). Simulation results for a quadruple-tank system show the effectiveness of the proposed approach.