High-throughput sequencing technologies consistently produce overwhelming amount of genomic data. This data is extremely important for the biomedical research and has an enormous impact on the progress in healthcare system. Considering the amount of generated sequencing data, data storage capacity became the principal concern for organizations like European Genome-phenome Archive (EGA) or Database of Genotypes and Phenotypes (dbGaP). The efficient and standard storage format is an important part of forging interoperability between different organizations. Several global initiatives such as ELIXIR and GA4GH already established the strategic partnership in standardization of genomic data formats andAPIs. On the other hand, other initiatives to provide a secure and efficient compressed format have appeared, such as MPEG-G (ISO/IEC 23092), developed by the MPEG working group of ISO (ISO/IEC JTC1 SC29/WG11). MPEG-G, also supported by ISO/TC 276 on Biotechnology, is making efforts for a better alignment and integration with approaches taken by other initiatives such as GA4GH.