Trajectory prediction and optimisation algorithms will be the keystone for a successful trajectory based operations concept implementation, where accurate predictions and optimal trajectories will be needed for a wide variety of look-ahead times and operational contexts. The main goal of this paper is to present the architecture and capabilities of an aircraft trajectory prediction and optimisation framework suitable for various air traffic management research applications. The flexibility of this framework, called DYNAMO, allows for an easy implementation and assessment of actual and future concepts of operation, considering at the same time realistic weather data and aircraft performance models. In addition, its design enables the use for real-time applications and when a large set of trajectories needs to be rapidly generated for simulation and benchmarking purposes. The performance of the framewor