Nonlinear amplitude dynamics in flagellar beating

Carregant...
Miniatura
El pots comprar en digital a:
El pots comprar en paper a:

Projectes de recerca

Unitats organitzatives

Número de la revista

Títol de la revista

ISSN de la revista

Títol del volum

Col·laborador

Editor

Tribunal avaluador

Realitzat a/amb

Tipus de document

Article

Data publicació

Editor

Condicions d'accés

Accés obert

item.page.rightslicense

Creative Commons
Aquesta obra està protegida pels drets de propietat intel·lectual i industrial corresponents. Llevat que s'hi indiqui el contrari, els seus continguts estan subjectes a la llicència de Creative Commons: Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional

Assignatures relacionades

Assignatures relacionades

Publicacions relacionades

Datasets relacionats

Datasets relacionats

Projecte CCD

Abstract

The physical basis of flagellar and ciliary beating is a major problem in biology which is still far from completely understood. The fundamental cytoskeleton structure of cilia and flagella is the axoneme, a cylindrical array of microtubule doublets connected by passive cross-linkers and dynein motor proteins. The complex interplay of these elements leads to the generation of self-organized bending waves. Although many mathematical models have been proposed to understand this process, few attempts have been made to assess the role of dyneins on the nonlinear nature of the axoneme. Here, we investigate the nonlinear dynamics of flagella by considering an axonemal sliding control mechanism for dynein activity. This approach unveils the nonlinear selection of the oscillation amplitudes, which are typically either missed or prescribed in mathematical models. The explicit set of nonlinear equations are derived and solved numerically. Our analysis reveals the spatio-temporal dynamics of dynein populations and flagellum shape for different regimes of motor activity, medium viscosity and flagellum elasticity. Unstable modes saturate via the coupling of dynein kinetics and flagellum shape without the need of invoking a nonlinear axonemal response. Hence, our work reveals a novel mechanism for the saturation of unstable modes in axonemal beating.

Descripció

Persones/entitats

Document relacionat

Versió de

Citació

Oriola, D.; Casademunt, J.; Bloomfield-Gadêlha, H. Nonlinear amplitude dynamics in flagellar beating. "Royal Society Open Science", 8 Març 2017, vol. 4, núm. 3, article 160698, p. 1-13.

Ajut

Forma part

Dipòsit legal

ISBN

ISSN

2054-5703

Altres identificadors

Referències