This paper reviews methodological approaches to the design (or redesign) of the supply chain (SC), including comprehensive approaches (proposals concerning the entire process of designing the SC) and those that deal with four specific aspects of the process (definition of the SC objectives, reverse SC, finance, and generation and use of scenarios) that have a decisive influence on the whole design of the SC. The comprehensive approaches include those based on typologies of products, markets and SCs and those that propose a succession of the stages to follow through the design process. The discussion shows that the use of typologies is not adequate to face SC design and that the methods proposing a succession of stages may suit, provided that they are developed and presented in a manner appropriate to their use for practitioners. The discussion leads also to suggest several research lines