This paper presents a single antenna ambient noise cancellation method for in-situ radiated emissions measurements performed using an entirely time-domain approach and the sliding window Empirical Mode Decomposition. The method requires a pair of successive measurements, an initial one for characterizing the ambient noise and a final one for the EMI measurement in the presence of ambient noise. The method assumes the spectral content of the ambient noise is stable between both measurements. The measured time-domain EMI is decomposed into a finite set of intrinsic mode functions. Some modes contain the ambient noise signals while other modes contain the actual components of the EMI. A brute-force search algorithm determines which mode, or combination of modes, maximize the absolute difference between the magnitude of their spectrum and the ambient noise levels for every frequency bin in the measurement bandwidth. Experimental results show the effectiveness of this method for attenuating several ambient noise signals in the 30 MHz – 1 GHz band.