Potential periodontal regeneration by application of monoclonal antibodies against integrin-subunits a6 and b1

Abstract

Successful guided tissue regeneration (GTR) should result in a functional attachment apparatus of the periodontium. The crucial points in the healing process are potential microbiological colonization of mechanical barrier membranes, lacking contact to the connective tissue and apical growth of the gingival epithelium. The membranes‘ success might be improved by equipping them with antibiotics, specific inhibitors for the epithelial growth and growth factors for periodontal ligament cells (PLC) or progenitor cells. Monoclonal antibodies (mAb) directed to integrin subunits a6 and b1 were tested for their specificity to epithelial growth. In vitro assays were performed as direct and indirect contact by seeding the human HaCaT-cell-line and gingival fibroblasts.