Since the conventional detector often fails to produce reliable decisions for a CDMA channel, several new multiuser detectors have previously proposed. In the present paper, the authors propose both a simple linear scheme for interference cancellation, which exhibits good performance, and a synchronism scheme based on the extended Kalman filter (EKF) to achieve synchronization among the different users at the base station, for a direct-sequence code-division multiple-access (DS/CDMA) synchronous system. The influence of the synchronism scheme on the performance of the interference canceller is analyzed under Rayleigh multipath fading.