Now showing items 1-11 of 11

    • Un desajuste en biotecnología 

      Cubarsí Morera, Rafael; Vázquez, Esther; Villaverde, Antonio (Escola Tècnica Superior d'Enginyers de Telecomunicació de Barcelona, 2011)
      Article
      Open Access
      Se modeliza la penetración de una versión modificada de la proteína verde fluorescente llamada GFP en el citoplasma y el núcleo de una célula de mamífero. El modelo matemático proporciona una primera aproximación ...
    • Endosomal escape of protein nanoparticles engineered through humanized histidine-rich peptides 

      Lopez Laguna, Hector; Cubarsí Morera, Rafael; Unzueta, Ugutz; Mangues, Ramón; Vazquez, Esther; Villaverde, Antonio (2019-12-27)
      Article
      Open Access
      Poly-histidine peptides such as H6 (HHHHHH) are used in protein biotechnologies as purification tags, pro- tein-assembling agents and endosomal-escape entities. The pleiotropic properties of such peptides make them appealing ...
    • Internalization and kinetics of nuclear migration of protein-only, arginine-rich nanoparticles 

      Vázquez, Esther; Cubarsí Morera, Rafael; Unzueta, Ugutz; Roldán, Mónica; Domingo-Espín, Joan; Ferrer-Miralles, Neus; Villaverde, Antonio (2010-12)
      Article
      Restricted access - publisher's policy
      Understanding the intracellular trafficking of nanoparticles internalized by mammalian cells is a critical issue in nanomedicine, intimately linked to therapeutic applications but also to toxicity concerns. While the uptake ...
    • Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles 

      Peasarrodona, Mireia; Crosas, Eva; Cubarsí Morera, Rafael; Vazquez, Esther; Villaverde, Antonio; et al., . (2017-04)
      Article
      Open Access
      Self-assembling proteins are gaining attention as building blocks for application-tailored nanoscale materials. This is mostly due to the biocompatibility, biodegradability, and functional versatility of peptide chains. ...
    • Mathematical model for fragmentation of bacterial inclusion bodies 

      Cubarsí Morera, Rafael; Carrió, M.M.; Villaverde, Antonio (Carles Casacuberta, Josep Maria Font, Santiago Zarzuela, 2000)
      Conference report
      Open Access
      Bacterial inclusion bodies are microscopic, ovoid-shaped aggregates of insoluble protein. Under protease exposure a digestion process is produced that reveals a variable fragmentation rate, not compatible with a surface ...
    • Modelling and parameter estimation of gene expression and cell growth in batch cultures 

      Cubarsí Morera, Rafael; Corchero, José Luis; Vila, Pau; Villaverde, Antonio (Carles Casacuberta, Josep Maria Font, Santiago Zarzuela, 2000)
      Conference report
      Open Access
      Experimental procedure of CI857ts-controlled recombinant gene expression in bacterial batch cultures is mathematically modelled, and the corresponding minimum variance parameters are estimated from specific statistical or ...
    • Proteine Bolognese 

      Cubarsí Morera, Rafael; Vázquez, Esther; Villaverde, Antonio (2011-06)
      Article
      Open Access
      Se modeliza la penetraci on de una versi on modi cada de la prote na verde uorescente llamada GFP en el citoplasma y el n ucleo de una c elula de mam fero. El modelo matem atico proporciona una primera aproximaci on ...
    • Proteine Bolognese 

      Cubarsí Morera, Rafael; Vázquez, Esther; Villaverde, Antonio (2010-06)
      Conference lecture
      Open Access
      Se modeliza la penetración de una versión modificada de la proteína verde fluorescente llamada GFP en el citoplasma y el núcleo de una célula de mamífero. El modelo matemático proporciona una primera aproximación al ...
    • Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP 

      Unzueta, Ugutz; Roldán Molina, Mónica; Pesarrodona, Mireia; Benítez Iglesias, Raúl; Sanchez Chardi, Alejandro; Conchillo, Oscar; Mangues, Ramón; Villaverde, Antonio; Vazquez Gómez, Esther (Elsevier, 2020-02-03)
      Article
      Open Access
      Fluorescent proteins are useful imaging and theranostic agents, but their potential superiority over alternative dyes is weakened by substantial photobleaching under irradiation. Enhancing protein photostability has been ...
    • Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides 

      Teixeira De Pinho Favaro, Marianna; Serna, Naroa; Sanchez Garcia, Laura; Cubarsí Morera, Rafael; Roldan, Monica; Sanchez Chardi, Alejandro; Unzueta, Ugutz; Mangues, Ramón; Ferrer Miralles, Neus; Rodrigues Azzoni, Adriano; Vazquez Gómez, Esther; Villaverde, Antonio (2018-08-01)
      Article
      Open Access
      Arginine-rich protein motifs have been described as potent cell-penetrating peptides (CPPs) but also as rather specific ligands of the cell surface chemokine receptor CXCR4, involved in the infection by the human ...
    • Un desajuste en biotecnologia 

      Cubarsí Morera, Rafael; Vázquez, Esther; Villaverde, Antonio (2011-09)
      Article
      Open Access
      Se modeliza la penetración de una versión modificada de la proteína verde fluorescente llamada GFP en el citoplasma y el núcleo de una célula de mamífero. El modelo matemático proporciona una primera aproximación ...