Browsing by Author "Vega, Miguel"
Now showing items 1-4 of 4
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Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death
(2016-01-01)
Article
Open AccessAstrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ... -
Discovery of novel 2,3,5-trisubstituted pyridine analogs as potent inhibitors of IL-1ß via modulation of the p38 MAPK signaling pathway
(2021-11-05)
Article
Open AccessInterleukin-1ß is a central mediator of innate immune responses and inflammation. It plays a key role in a wide variety of pathologies, ranging from autoinflammatory diseases to metabolic syndrome and malignant tumors. It ... -
Identification of a novel inhibitory allosteric site of MAP kinases
(2016-11-29)
Article
Open AccessIn the present study, we report the discovery of a novel allosteric inhibitory site for p38a, a subclass of the mitogen-activated protein kinases (MAPK) family. The putative site was discovered after inspection of the ... -
Structure-activity studies of novel Di-substituted [1,2,5]oxadiazolo [3,4-b]pyrazine analogs targeting the A-loop regulatory site of p38 MAP kinase
(Bentham Science Publishers, 2022-03-01)
Article
Restricted access - publisher's policyIntroduction: In the quest for novel allosteric inhibitors of the p38 MAP kinase, we recently described the A-loop regulatory site, identified by means of molecular modeling studies together with the disclosure of a small ...
