Now showing items 1-2 of 2

  • Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death 

    Fernandez, Ana M.; Hervas, Ruben; Dominguez Fraile, Manuel; Garrido Victoria, Navarro; Gómez Gutiérrez, Patricia; Vega, Miguel; Vitorica, Javier; Pérez González, Juan Jesús; Torres Aleman, Ignacio (2016-01-01)
    Article
    Open Access
    Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ...
  • Identification of a novel inhibitory allosteric site of MAP kinases 

    Gomez-Gutierrez, Patricia; Campos Muelas, Pedro Manuel; Vega, Miguel; Pérez González, Juan Jesús (2016-11-29)
    Article
    Open Access
    In the present study, we report the discovery of a novel allosteric inhibitory site for p38a, a subclass of the mitogen-activated protein kinases (MAPK) family. The putative site was discovered after inspection of the ...