Now showing items 1-2 of 2

  • In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27 

    Acosta Reyes, Francisco Javier; Dardonville, Cristophe Y.; De Koning, Harry Pieter; Natto, Manal J.; Subirana, Juan Antonio; Campos López, Josefina de Lourdes (2014-06)
    Article
    Open Access
    The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies ...
  • Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds 

    Acosta Reyes, Francisco Javier; Subirana, Juan Antonio; Campos López, Josefina de Lourdes; Alechaga, Elida (2015-03-17)
    Article
    Open Access
    The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is ...