Browsing by Author "Santiago, Gerard"
Now showing items 1-8 of 8
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Computer-aided laccase engineering: toward biological oxidation of arylamines
Santiago, Gerard; de Salas, Felipe; Lucas, Fatima; Monza, Emanuele; Acebes, Sandra; Martinez, Ángel T.; Camarero, Susana (ACS Publications, 2016-07-08)
Article
Open AccessOxidation of arylamines, such as aniline, is of high industrial interest and laccases have been proposed as biocata-lysts to replace harsh chemical oxidants. However, the reaction is hampered by the redox potential of the ... -
Controlled manipulation of enzyme specificity through immobilization-induced flexibility constraints
Coscolín, Cristina; Beloqui, Ana; Martínez-Martínez, Mónica; Bargiela, Rafael; Santiago, Gerard; Blanco, Rosa M.; Delaittre, Guillaume; Márquez-Álvarez, Carlos; Ferrer, Manuel (Elsevier, 2018-09-05)
Article
Open AccessIt is thought that during immobilization enzymes, as dynamic biomolecules, may become distorted and this may alter their catalytic properties. However, the effects of different immobilization strategies on enzyme rigidity ... -
Esterases computational study
Cañadas, Ruben; Santiago, Gerard; Guallar, Victor (Barcelona Supercomputing Center, 2017-05-04)
Conference report
Open AccessIn our project, we are focusing on two different esterases called LAE6 and LAE5. LAE6 is very promiscuous since it presents activity towards a wide range of different substrates, whereas LAE5 presents activity towards few ... -
PluriZymes: new enzymes for new times
Domingo-Cabasés, Marc; Rodà, Sergi; Santiago, Gerard; Guallar, Victor (Barcelona Supercomputing Center, 2019-05-07)
Conference report
Open Access -
Protein modelling for enzyme engineering
Santiago, Gerard; Guallar, Victor (Barcelona Supercomputing Center, 2017-05-04)
Conference report
Open Access -
Rational Engineering of Multiple Active Sites in an Ester Hydrolase
Santiago, Gerard; Martínez-Martínez, Mónica; Alonso, Sandra; Bargiela, Rafael; Coscolín, Cristina; Golyshing, Peter N.; Guallar, Victor; Ferrer, Manuel (American Chemical Society, 2018-03-30)
Article
Open AccessEffects of altering the properties of an active site in an enzymatic homogeneous catalyst have been extensively reported. However, the possibility of increasing the number of such sites, as commonly done in heterogeneous ... -
Re-designing the substrate binding pocket of laccase for enhanced oxidation of sinapic acid
Pardo, Isabel; Santiago, Gerard; Gentili, Patrizia; Lucas, Fátima; Monza, Emanuele; Medrano, Francisco Javier; Galli, Carlo; Martínez, Angel T.; Guallar, Víctor; Camarero, Susana (Royal Society of Chemistry, 2015-12-29)
Article
Open AccessIterative saturation mutagenesis was performed over six residues delimiting the substrate binding pocket of a high redox potential chimeric laccase with the aim of enhancing its activity over sinapic acid, a ligninrelated ... -
Towards PET degradation engineering
Rodà, Sergi; Santiago, Gerard; Guallar, Victor (Barcelona Supercomputing Center, 2019-05-07)
Conference report
Open Access