Browsing by Author "Rietveld, Ivo B."
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[60]Fullerene for medicinal purposes, a purity criterion towards regulatory considerations
Keykhosravi, Sanaz; Rietveld, Ivo B.; Couto, Diana; Tamarit Mur, José Luis; Barrio Casado, María del; Céolin, René; Moussa, Fathi (Multidisciplinary Digital Publishing Institute (MDPI), 2019-08-01)
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Open AccessSince the early nineties countless publications have reported promising medicinal applications for [60]fullerene (C60) related to its unparalleled affinity towards free radicals. Yet, until now no officially approved ... -
A thermodynamically consistent phase diagram of a trimorphic pharmaceutical, L-tyrosine ethyl ester, based on limited experimental data
Nicolaï, Béatrice; Barrio Casado, María del; Lloveras Muntané, Pol Marcel; Polian, Alain; Itié, Jean-Paul; Tamarit Mur, José Luis; Rietveld, Ivo B. (Royal Society of Chemistry (RSC), 2018-08-29)
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An integrated view of theiInfluence of temperature, pressure, and humidity on the stability of trimorphic cysteamine hydrochloride
Gana, Inès; Barrio Casado, María del; Ghaddar, Carine; Nicolai, Beatrice; Do, Bernard; Tamarit Mur, José Luis; Safta, Fathi; Rietveld, Ivo B. (2015-07-01)
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Open AccessUnderstanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after the incident with ritonavir. In the present paper, a comprehensive study of the ... -
An order-disorder phase transition in the van der Waals based solvate of C60 and CClBrH2
Ye, Jin; Barrio Casado, María del; Céolin, René; Qureshi, Navid; Negrier, Philippe; Rietveld, Ivo B.; Tamarit Mur, José Luis (2018-04-04)
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Open AccessThe co-crystal of C60·2CBrClH2 possesses a monoclinic (C2/m) structure at room temperature with both molecular entities, C60 and CBrClH2, orientationally ordered. At 322 K, it transforms reversibly into a hexagonal (P6/mmm) ... -
Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III
Gana, Inès; Barrio Casado, María del; Do, Bernard; Tamarit Mur, José Luis; Céolin, René; Rietveld, Ivo B. (2013-11-18)
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Restricted access - publisher's policytUnderstanding the phase behavior of an active pharmaceutical ingredient in a drug formulation isrequired to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in amarketed product. ... -
Crystal structure and solid-state properties of 3,4-diaminopyridine dihydrogen phosphate and their comparison with other diaminopyridine salts
Mahe, N.; Nicolaï, B.; Allouchi, Hassan; Barrio Casado, María del; Do, Bernat; Céolin, René; Tamarit Mur, José Luis; Rietveld, Ivo B. (2013-02)
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Restricted access - publisher's policy3,4-Diaminopyridine is an active pharmaceutical ingredient for the treatment of Lambert−Eaton myasthenic syndrome (LEMS). It is 3,4-diaminopyridine dihydrogen phosphate that has become the active ingredient of choice. As ... -
Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension
Teulon, Jean-Marie; Mahé, Nathalie; Do, Bernard; Nicolaï, Béatrice; Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis; Céolin, René; Ghéchot, Christophe (2012)
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Restricted access - publisher's policyAging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference ... -
Crystal structures and phase relationships of 2 polymorphs of 1,4-Diazabicyclo[3.2.2]nonane-4-Carboxylic Acid 4-Bromophenyl Ester Fumarate, A selective a-7 nicotinic receptor partial agonist
Robert, Benoit; Perrin, Marc-Antoine; Barrio Casado, María del; Tamarit Mur, José Luis; Coquerel, Gerard; Céolin, René; Rietveld, Ivo B. (2016-01)
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Open AccessTwo polymorphs of the 1:1 fumarate salt of 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester, developed for the treatment of cognitive symptoms of schizophrenia and Alzheimer disease, have been characterized. ... -
Enantiomer resolution by pressure increase: inferences from experimental and topological results for the binary enantiomer system (R)- and (S)-mandelic acid
Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis; Do, Bernard; Céolin, René (2011-11-02)
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Restricted access - publisher's policyIn pharmacy, racemic compounds are often problematic, because generally only one of the enantiomers possesses therapeutic activity and it is often difficult to separate them. Even though this problem is likely as old ... -
Experimental and topological determination of the pressure-temperature phase diagram of morniflumate, a pharmaceutical ingredient with anti-inflammatory properties
Barrio Casado, María del; Tamarit Mur, José Luis; Céolin, René; Robert, Benoit; Guechot, C.; Teulon, J.M.; Rietveld, Ivo B. (2017-09-01)
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Open AccessThe pressure-temperature phase diagram of morniflumate (niflumic acid ß-morpholinoethyl ester) has been obtained by high-pressure thermal analysis. In addition, calorimetric melting data (TI¿L = (348.1 ± 0.4) K and ¿HI¿L ... -
Experimental and topological determination of the pressure-temperature phase diagram of racemic etifoxine, a pharmaceutical ingredient with anxiolytic properties
Barrio Casado, María del; Allouchi, Hassan; Tamarit Mur, José Luis; Céolin, René; Berthon-Cédille, Laurence; Rietveld, Ivo B. (2019-12-18)
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Restricted access - publisher's policyInformation about the solid-state properties of etifoxine has been lacking, even if the active pharmaceutical ingredient has been used for its anxiolytic properties for decennia. The crystal structure of the racemic compound ... -
Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies
Sadou Yayé, Hassane; Rietveld, Ivo B.; Barrio Casado, María del; Secrétan, Philippe-Henri; Faucheron, Antoine; Karoui, Maher; Tilleul, Patrick; Yagoubi, Najet; Do, Bernard (2017-09-30)
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Open AccessThe mainstay treatment for patients with acute coronary syndrome is an oral route dual antiplatelet therapy with a P2Y12-receptor antagonist and Aspirin (ASA). To improve patient adherence to such treatments, combination ... -
Liquid-liquid miscibility gaps in drug-water binary systems: crystal Structure and thermodynamic properties of prilocaine and the temperature-composition phase diagram of the prilocaine-water system
Rietveld, Ivo B.; Perrin, Jean-Claude; Toscani, Siro; Barrio Casado, María del; Nicolai, Beatrice; Tamarit Mur, José Luis; Céolin, René (2013-04)
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Restricted access - publisher's policyEMLA cream, a “eutectic mixture of local anesthetics”, was developed in the early 1980s by Astra Pharmaceutical Production. The mixture of anesthetics containing lidocaine, prilocaine, and water is liquid at room ... -
On the polymorphism of l -citrulline: Crystal structure and characterization of the orthorhombic d form
Allouchi, Hassan; Nicolai, Beatrice; Barrio Casado, María del; Céolin, René; Mahé, Nathalie; Tamarit Mur, José Luis; Do, Bernard; Rietveld, Ivo B. (2014-03-01)
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Restricted access - publisher's policySolid-state properties of active pharmaceutical compounds are closely related to their dissolution behavior and bioavailability, and understanding their phase behavior leads to better control in the drug formulation process. ... -
Ordered and disordered solvates of C 60 and CBrCl 2 H
Ye, Jin; Barrio Casado, María del; Céolin, René; Qureshi, Navid; Negrier, Philippe; Rietveld, Ivo B.; Tamarit Mur, José Luis (2019-01-01)
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Open AccessThe formation of co-crystals is often unexpected; however, the Buckminster fullerene, for which many solvates are known,is an excellent system to study this tendency. In the present paper, C60 and CBrCl2H co-crystals have ... -
Orientational order in the stable buckminster fullerene solvate C60·2CBr2H2
Ye, Jin; Barrio Casado, María del; Negrier, Philippe; Qureshi, Navid; Rietveld, Ivo B.; Céolin, René; Tamarit Mur, José Luis (2017-04-01)
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Open AccessCrystals of the solvate C60·2CBr2H2 (monoclinic C2/m), which is stable in air, were grown by slow evaporation of solutions of C60 in CBr2H2 at room temperature. The high enthalpy change for the complete desolvation process, ... -
Overall stability for the ibuprofen racemate: experimental and topological results leading to the pressure-temperature phase relationships between its racemate and conglomerate
Rietveld, Ivo B.; Barrio Casado, María del; Do, Bernard; Tamarit Mur, José Luis; Céolin, René (2012-05-10)
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Restricted access - publisher's policyEnantiomer resolution is much sought after for pharmaceutical applications, because many optically active drug molecules have only one pharmaceutically active enantiomer. Although it is always possible to force separation, ... -
Pitfalls and feedback when constructing topological pressure-temperature phase diagrams
Céolin, René; Toscani, Siro; Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis (2017-04-18)
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Open AccessThe stability hierarchy between different phases of a chemical compound can be accurately reproduced in a topological phase diagram. This type of phase diagrams may appear to be the result of simple extrapolations, however, ... -
Polymorphism of spironolactone: An unprecedented case of monotropy turning to enantiotropy with a huge difference in the melting temperatures
Rietveld, Ivo B.; Barrio Casado, María del; Lloveras Muntané, Pol Marcel; Céolin, René; Tamarit Mur, José Luis (2018-09-25)
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Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide
Barrio Casado, María del; Huguet, Jordi; Robert, B.; Rietveld, Ivo B.; Céolin, René; Tamarit Mur, José Luis (2017-06-15)
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Open AccessUnderstanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however ...