Browsing by Author "Rietveld, Ivo B."
Now showing items 1-20 of 31
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[60]Fullerene for medicinal purposes, a purity criterion towards regulatory considerations
(Multidisciplinary Digital Publishing Institute (MDPI), 2019-08-01)
Article
Open AccessSince the early nineties countless publications have reported promising medicinal applications for [60]fullerene (C60) related to its unparalleled affinity towards free radicals. Yet, until now no officially approved ... -
An integrated view of theiInfluence of temperature, pressure, and humidity on the stability of trimorphic cysteamine hydrochloride
(2015-07-01)
Article
Open AccessUnderstanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after the incident with ritonavir. In the present paper, a comprehensive study of the ... -
An order-disorder phase transition in the van der Waals based solvate of C60 and CClBrH2
(2018-04-04)
Article
Open AccessThe co-crystal of C60·2CBrClH2 possesses a monoclinic (C2/m) structure at room temperature with both molecular entities, C60 and CBrClH2, orientationally ordered. At 322 K, it transforms reversibly into a hexagonal (P6/mmm) ... -
A thermodynamically consistent phase diagram of a trimorphic pharmaceutical, L-tyrosine ethyl ester, based on limited experimental data
(Royal Society of Chemistry (RSC), 2018-08-29)
Article
Open Access -
Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III
(2013-11-18)
Article
Restricted access - publisher's policytUnderstanding the phase behavior of an active pharmaceutical ingredient in a drug formulation isrequired to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in amarketed product. ... -
Crystal structure and solid-state properties of 3,4-diaminopyridine dihydrogen phosphate and their comparison with other diaminopyridine salts
(2013-02)
Article
Restricted access - publisher's policy3,4-Diaminopyridine is an active pharmaceutical ingredient for the treatment of Lambert−Eaton myasthenic syndrome (LEMS). It is 3,4-diaminopyridine dihydrogen phosphate that has become the active ingredient of choice. As ... -
Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension
(2012)
Article
Restricted access - publisher's policyAging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference ... -
Crystal structures and phase relationships of 2 polymorphs of 1,4-Diazabicyclo[3.2.2]nonane-4-Carboxylic Acid 4-Bromophenyl Ester Fumarate, A selective a-7 nicotinic receptor partial agonist
(2016-01)
Article
Open AccessTwo polymorphs of the 1:1 fumarate salt of 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester, developed for the treatment of cognitive symptoms of schizophrenia and Alzheimer disease, have been characterized. ... -
Enantiomer resolution by pressure increase: inferences from experimental and topological results for the binary enantiomer system (R)- and (S)-mandelic acid
(2011-11-02)
Article
Restricted access - publisher's policyIn pharmacy, racemic compounds are often problematic, because generally only one of the enantiomers possesses therapeutic activity and it is often difficult to separate them. Even though this problem is likely as old ... -
Experimental and topological determination of the pressure-temperature phase diagram of morniflumate, a pharmaceutical ingredient with anti-inflammatory properties
(2017-09-01)
Article
Open AccessThe pressure-temperature phase diagram of morniflumate (niflumic acid ß-morpholinoethyl ester) has been obtained by high-pressure thermal analysis. In addition, calorimetric melting data (TI¿L = (348.1 ± 0.4) K and ¿HI¿L ... -
Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies
(2017-09-30)
Article
Open AccessThe mainstay treatment for patients with acute coronary syndrome is an oral route dual antiplatelet therapy with a P2Y12-receptor antagonist and Aspirin (ASA). To improve patient adherence to such treatments, combination ... -
Liquid-liquid miscibility gaps in drug-water binary systems: crystal Structure and thermodynamic properties of prilocaine and the temperature-composition phase diagram of the prilocaine-water system
(2013-04)
Article
Restricted access - publisher's policyEMLA cream, a “eutectic mixture of local anesthetics”, was developed in the early 1980s by Astra Pharmaceutical Production. The mixture of anesthetics containing lidocaine, prilocaine, and water is liquid at room ... -
On the polymorphism of l -citrulline: Crystal structure and characterization of the orthorhombic d form
(2014-03-01)
Article
Restricted access - publisher's policySolid-state properties of active pharmaceutical compounds are closely related to their dissolution behavior and bioavailability, and understanding their phase behavior leads to better control in the drug formulation process. ... -
Orientational order in the stable buckminster fullerene solvate C60·2CBr2H2
(2017-04-01)
Article
Open AccessCrystals of the solvate C60·2CBr2H2 (monoclinic C2/m), which is stable in air, were grown by slow evaporation of solutions of C60 in CBr2H2 at room temperature. The high enthalpy change for the complete desolvation process, ... -
Overall stability for the ibuprofen racemate: experimental and topological results leading to the pressure-temperature phase relationships between its racemate and conglomerate
(2012-05-10)
Article
Restricted access - publisher's policyEnantiomer resolution is much sought after for pharmaceutical applications, because many optically active drug molecules have only one pharmaceutically active enantiomer. Although it is always possible to force separation, ... -
Pitfalls and feedback when constructing topological pressure-temperature phase diagrams
(2017-04-18)
Article
Open AccessThe stability hierarchy between different phases of a chemical compound can be accurately reproduced in a topological phase diagram. This type of phase diagrams may appear to be the result of simple extrapolations, however, ... -
Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide
(2017-06-15)
Article
Open AccessUnderstanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however ... -
Pressure–temperature state diagram for the phase relationships between benfluorex hydrochloride forms I and II: A case of enantiotropic behavior
(2011-11-03)
Article
Restricted access - publisher's policyThe active pharmaceutical ingredient racemic benfluorex hydrochloride (benfluorex–HCl) has an interesting phase behavior due to an elusive solid–solid phase transition. The stability hierarchy between different phases is ... -
Rimonabant dimorphism and its pressure–temperature phasegiagram: A delicate case of overall monotropic behavior
(2013-05-20)
Article
Restricted access - publisher's policyCrystalline polymorphism occurs frequently in the solid state of active pharmaceutical ingredients, and this is problematic for the development of a suitable dose form. Rimonabant, an active pharmaceutical ingredient ...
