Now showing items 1-10 of 10

  • A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins 

    Kapp, Tobias G.; Rechenmacher, Florian; Neubauer, Stefanie; Maltsev, Oleg V.; Cavalcanti-Adam, Elisabetta Ada; Zarka, Revital; Reuning, Ute; Notni, Johannes; Wester, Hans-Jürgen; Mas Moruno, Carlos; Spatz, Joachim; Geiger, Benjamin; Kessler, Horst (Macmillan Publishers, 2017-01-11)
    Article
    Open Access
    Covenantee:  Technische Universität München
    Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in ...
  • A molecular toolkit for the functionalization of titanium-based biomaterials that selectively control integrin-mediated cell adhesion 

    Rechenmacher, Florian; Neubauer, Stefanie; Mas Moruno, Carlos (2013-06-06)
    Article
    Restricted access - publisher's policy
    We present a click chemistry- based molecular toolkit for the bio- functionalization of materials to selec- tively control integrin-mediated cell ad- hesion. To this end, a 5 b 1-selective RGD peptidomimetics were ...
  • avß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating 

    Mas Moruno, Carlos; Fraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie; Kapp, Tobias G.; Kessler, Horst (2016-06-13)
    Article
    Open Access
    Covenantee:  Technische Universität München
    Engineering biomaterials with integrin-binding activity is a very powerful approach to promote cell adhesion, modulate cell behavior, and induce specific biological responses at the surface level. The aim of this Review ...
  • Functionalizing avß3- or a5ß1-selective integrin antagonists for surface coating: A new tool to discriminate integrin subtypes in vitro 

    Rechenmacher, Florian; Neubauer, Stefanie; Polleux, Julien; Mas Moruno, Carlos; De Simone, Mariarosaria; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim P.; Fässler, Reinhard; Kessler, Horst (2013)
    Article
    Restricted access - publisher's policy
    Thumbnail image of graphical abstract Stuck with the right choice: avß3- or a5ß1-selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured ...
  • Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium 

    Fraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie; Manero Planella, José María; Gil Mur, Francisco Javier; Kessler, Horst; Mas Moruno, Carlos (2015-04-01)
    Article
    Open Access
    Covenantee:  Technische Universität München
    Interaction between the surface of implants and biological tissues is a key aspect of biomaterials research. Apart from fulfilling the non-toxicity and structural requirements, synthetic materials are asked to direct cell ...
  • Novel peptide-based strategies to install osteointegrative properties on metallic biomaterials 

    Fraioli, Roberta; Neubauer, Stefanie; Rechenmacher, Florian; Manero Planella, José María; Kessler, Horst; Gil Mur, Francisco Javier; Mas Moruno, Carlos (2015)
    Conference lecture
    Open Access
    Covenantee:  Technische Universität München
  • Pharmacophoric modifications lead to superpotent avß3 integrin ligands with suppressed a5ß1 activity 

    Neubauer, Stefanie; Rechenmacher, Florian; Brimioulle, Richard; Di Leva, Francisco Saverio; Bochen, Alexander; Sobahi, Tariq R.; Schottelius, Margret; Novellino, Ettore; Mas Moruno, Carlos; Marinelli, Luciana; Kessler, Horst (2014-04-24)
    Article
    Restricted access - publisher's policy
    Covenantee:  Technische Universität München
    The selective targeting of the avß3 integrin subtype without affecting the structurally closely related receptor a5ß1 is crucial for understanding the details of their biological and pathological functions and thus of great ...
  • The integrin ligand c(RGDf(NMe)Nal) reduces neointimal hyperplasia in a polymer-free drug-eluting stent system 

    Rechenmacher, Florian; Steigerwald, Kristin; Laufer, Burkhardt; Neubauer, Stefanie; Kapp, Tobias G.; Li, Liang; Mas Moruno, Carlos; Joner, Michael; Kessler, Horst (2014-07-01)
    Article
    Restricted access - publisher's policy
    Covenantee:  Technische Universität München / Deutsches Herzzentrum München / CVPath Institute
    The use of highly active and selective integrin ligands in combination with stent implantation is emerging as a promising alternative to the release of classical immunosuppressive drugs by current drug-eluting stents (DES), ...
  • Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands 

    Fraioli, Roberta; Tsimbouri, Penelope M.; Fisher, Leanne E.; Nobbs, Angela H.; Su, Bo; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Ginebra Molins, Maria Pau; Dalby, Matthew J.; Manero Planella, José María; Mas Moruno, Carlos (Macmillan Publishers, 2017-11-27)
    Article
    Open Access
    Covenantee:  Technische Universität München / University of Bristol. Bristol Dental School
    Engineering the interface between biomaterials and tissues is important to increase implant lifetime and avoid failures and revision surgeries. Permanent devices should enhance attachment and differentiation of stem cells, ...
  • Tumor targeting via integrin ligands 

    Marelli, Udaya Kiran; Rechenmacher, Florian; Sobahi, Tariq Rashad Ali; Mas Moruno, Carlos; Kessler, Horst (2013)
    Article
    Open Access
    Selective and targeted delivery of drugs to tumors is a major challenge for an effective cancer therapy and also to overcome the side-effects associated with current treatments. Overexpression of various receptors on tumor ...