Browsing by Subject "Proteins"
Now showing items 1-20 of 59
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3D structure of a Brucella melitensis porin: molecular modelling in lipid membranes
(2018-01-01)
Article
Open AccessBrucella melitensis is a pathogenic bacterium responsible for brucellosis in mammals and humans. Its outer membrane proteins (Omp) control the diffusion of solutes through the membrane, and they consequently have a crucial ... -
A step forward toward selective activation/inhibition of bak, a pro-apoptotic member of the Bcl-2 protein family: discovery of new prospective allosteric sites using molecular dynamics
(American Chemical Society, 2023-01-01)
Article
Open AccessBak is a pro-apoptotic protein and a member of the Bcl-2 family that plays a key role in apoptosis, a programmed cell death mechanism of multicellular organisms. Its activation under death stimuli triggers the permeabilization ... -
Altered trafficking and unfolded protein response induction as a result of M3 muscarinic receptor impaired N-glycosylation
(2011-12)
Article
Restricted access - publisher's policy -
Amphipathic solvation of indole: implications for the role of tryptophan in membrane proteins
(2015-05-14)
Article
Open AccessThe microscopic structure of the tryptophan side chain, indole, in an amphiphilic environment has been investigated using a combination of neutron diffraction measurements and simulations in solution. The results show that ... -
An optimized TOPS+ comparison method for enhanced TOPS models
(2010-03-17)
Article
Open AccessBackground: Although methods based on highly abstract descriptions of protein structures, such as VAST and TOPS, can perform very fast protein structure comparison, the results can lack a high degree of biological significance. ... -
Anaerobic digestion of animal by-products and slaughterhouse waste: main process limitations and microbial community interactions
(2011-02-01)
Article
Restricted access - publisher's policyFresh pig/cattle slaughterhouse waste mixtures, with different lipid-protein ratios, were characterized and their anaerobic biodegradability assessed in batch tests. The resultant methane potentials were high (270–300 LCH4 ... -
Anàlisi i optimització de l'aplicació bioinformàtica de docking: Lightdock
(Universitat Politècnica de Catalunya, 2015-01-26)
Bachelor thesis
Open Access[CATALÀ] En aquest projecte es realitza una anàlisi de Lightdock, una aplicació de protein docking, i es detallen un seguit d'optimitzacions amb l'objectiu de reduir del temps d'execució del programa. Finalment es proposen ... -
APPRIS 2017: principal isoforms for multiple gene sets
(Oxford University Press (OUP), 2017-10-23)
Article
Open AccessThe APPRIS database (http://appris-tools.org) uses protein structural and functional features and information from cross-species conservation to annotate splice isoforms in protein-coding genes. APPRIS selects a single ... -
Asymmetric sulfoxidation by engineering the heme pocket of a dye-decolorizing peroxidase
(Royal Society of Chemistry, 2016-05-23)
Article
Open AccessThe so-called dye-decolorizing peroxidases (DyPs) constitute a new family of proteins exhibiting remarkable stability. With the aim of providing them new catalytic activities of biotechnological interest, the heme pocket ... -
avß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating
(2016-06-13)
Article
Open Access
Covenantee: Technische Universität MünchenEngineering biomaterials with integrin-binding activity is a very powerful approach to promote cell adhesion, modulate cell behavior, and induce specific biological responses at the surface level. The aim of this Review ... -
Biofunctionalized self-propelled micromotors as an alternative on-chip concentrating system
(2014-05-29)
Article
Restricted access - publisher's policySample pre-concentration is crucial to achieve high sensitivity and low detection limits in lab-on-a-chip devices. Here, we present a system in which self-propelled catalytic micromotors are bio-functionalized and trapped ... -
Biomimetic engineering of conductive curli protein films
(2018-09-11)
Article
Open AccessBioelectronic systems derived from peptides and proteins are of particular interest for fabricating novel flexible, biocompatible and bioactive devices. These synthetic or recombinant systems designed for mediating electron ... -
Computer-aided laccase engineering: toward biological oxidation of arylamines
(ACS Publications, 2016-07-08)
Article
Open AccessOxidation of arylamines, such as aniline, is of high industrial interest and laccases have been proposed as biocata-lysts to replace harsh chemical oxidants. However, the reaction is hampered by the redox potential of the ... -
Conformational Heterogeneity of Unbound Proteins Enhances Recognition in Protein–Protein Encounters
(American Chemical Society, 2016-06-20)
Article
Open AccessTo understand cellular processes at the molecular level we need to improve our knowledge of protein−protein interactions, from a structural, mechanistic, and energetic point of view. Current theoretical studies and ... -
CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19
(Mary Ann Liebert, 2020)
Article
Open AccessIntroduction: We introduce in this study CovMulNet19, a comprehensive COVID-19 network containing all available known interactions involving SARS-CoV-2 proteins, interacting-human proteins, diseases and symptoms that are ... -
Deep Learning for Protein Function Prediction
(Universitat Politècnica de Catalunya, 2017-09-26)
Master thesis
Open Access
Covenantee: Technische Universität MünchenThe assignment of functions to proteins is a bottleneck due to the need of costly and time-consuming molecular experiments. This is the reason why more often data analysis methods are used for protein an- notation. In this ... -
Determination of photophysical properties of photoactivatable fluorescent proteins for quantitative super-resolution imaging
(Universitat Politècnica de Catalunya, 2012-09-02)
Master thesis
Open Access[ANGLÈS] This project aims to characterize these photophysical properties such as photobleaching and photoconversion of the photoconvertible fluorescent preotein mEos2 in vitro. It slightly approaches the characterization ... -
Discovery of hit compounds targeting the P4 allosteric site of K-RAS, identified through ensemble-based virtual screening
(American Chemical Society, 2023-10-12)
Article
Open AccessMutants of Ras are oncogenic drivers of a large number of human tumors. Despite being recognized as an attractive target for the treatment of cancer, the high affinity for its substrate tagged the protein as undruggable ... -
Diseño de una planta de producción de un biosimilar de Etanercept
(Universitat Politècnica de Catalunya, 2018-10-31)
Master thesis
Restricted access - author's decisionLa pérdida de los derechos de patente sobre uno de los principios activos superventas de los últimos años, Etanercept – empleado como agente terapéutico contra enfermedades inmunosupresoras como la psoriasis y la artritis ... -
Docosahexaenoic acid phospholipid differentially modulates the conformation of G90V and N55K rhodopsin mutants associated with retinitis pigmentosa
(2017-05-01)
Article
Open AccessRhodopsin is the visual photoreceptor of the retinal rod cells that mediates dim light vision and a prototypical member of the G protein-coupled receptor superfamily. The structural stability and functional performance of ...
