Browsing by Subject "Proteïnes"
Now showing items 1-20 of 62
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3D structure of a Brucella melitensis porin: molecular modelling in lipid membranes
(2018-01-01)
Article
Open AccessBrucella melitensis is a pathogenic bacterium responsible for brucellosis in mammals and humans. Its outer membrane proteins (Omp) control the diffusion of solutes through the membrane, and they consequently have a crucial ... -
A step forward toward selective activation/inhibition of bak, a pro-apoptotic member of the Bcl-2 protein family: discovery of new prospective allosteric sites using molecular dynamics
(American Chemical Society, 2023-01-01)
Article
Open AccessBak is a pro-apoptotic protein and a member of the Bcl-2 family that plays a key role in apoptosis, a programmed cell death mechanism of multicellular organisms. Its activation under death stimuli triggers the permeabilization ... -
A theoretical multiscale treatment of protein-protein electron transfer: the ferredoxin/ferredoxin-NADP+ reductase and flavodoxin/ferredoxin-NADP+ reductase systems
(Elsevier, 2015-12)
Article
Open AccessIn the photosynthetic electron transfer (ET) chain, two electrons transfer from photosystem I to the flavin- dependent ferredoxin-NADP+ reductase (FNR) via two sequential independent ferredoxin (Fd) electron carriers. In ... -
Altered trafficking and unfolded protein response induction as a result of M3 muscarinic receptor impaired N-glycosylation
(2011-12)
Article
Restricted access - publisher's policy -
Amphipathic solvation of indole: implications for the role of tryptophan in membrane proteins
(2015-05-14)
Article
Open AccessThe microscopic structure of the tryptophan side chain, indole, in an amphiphilic environment has been investigated using a combination of neutron diffraction measurements and simulations in solution. The results show that ... -
Anàlisi i optimització de l'aplicació bioinformàtica de docking: Lightdock
(Universitat Politècnica de Catalunya, 2015-01-26)
Bachelor thesis
Open Access[CATALÀ] En aquest projecte es realitza una anàlisi de Lightdock, una aplicació de protein docking, i es detallen un seguit d'optimitzacions amb l'objectiu de reduir del temps d'execució del programa. Finalment es proposen ... -
Asymmetric sulfoxidation by engineering the heme pocket of a dye-decolorizing peroxidase
(Royal Society of Chemistry, 2016-05-23)
Article
Open AccessThe so-called dye-decolorizing peroxidases (DyPs) constitute a new family of proteins exhibiting remarkable stability. With the aim of providing them new catalytic activities of biotechnological interest, the heme pocket ... -
avß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating
(2016-06-13)
Article
Open Access
Covenantee: Technische Universität MünchenEngineering biomaterials with integrin-binding activity is a very powerful approach to promote cell adhesion, modulate cell behavior, and induce specific biological responses at the surface level. The aim of this Review ... -
Catalytic surface radical in dye-decolorizing peroxidase: A computational, spectroscopic and directed mutagenesis study
(Portland Press, 2015-03-01)
Article
Open AccessDye-decolorizing peroxidase (DyP) of Auricularia auriculajudae has been expressed in Escherichia coli as a representative of a new DyP family, and subjected to mutagenic, spectroscopic, crystallographic and computational ... -
Citotoxicidad de suavizantes catiónicos sobre una línea celular establecida de mamífero.
(Instituto de Investigación Textil y Cooperación Industrial, 1994-01)
Article
Open AccessEste articulo expone de forma detallada el proceso de determinación de la toxicidad de cuatro suavizantes catiónicos de uso textil, mediante técnicas in vitro con cultivos celulares. Se ha utilizado como parámetro de ... -
Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor
(Wiley Online Library, 2015-11-10)
Article
Open AccessThe modulation of protein–protein interactions (PPIs) is emerging as a highly promising tool to fight diseases. However, whereas an increasing number of compounds are able to disrupt peptide-mediated PPIs efficiently, the ... -
Comportamiento detersivo de las formulaciones ecológicas en la extracción de grasas y proteínas en tejido de algodón aprestado y tratado con diversos suavizantes
(Instituto de Investigación Textil y Cooperación Industrial, 2002-01)
Article
Open AccessEn el presente trabajo se efectuó un estudio del comportamiento detersivo producido por una formulación ecológica, aplicada para el lavado de un tejido de algodón aprestado con una resina DMDHEU y tratado con diferentes ... -
Deep Learning for Protein Function Prediction
(Universitat Politècnica de Catalunya, 2017-09-26)
Master thesis
Open Access
Covenantee: Technische Universität MünchenThe assignment of functions to proteins is a bottleneck due to the need of costly and time-consuming molecular experiments. This is the reason why more often data analysis methods are used for protein an- notation. In this ... -
Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish
(2022-05-02)
Article
Open AccessGenetic variants in YWHAZ contribute to psychiatric disorders such as autism spectrum disorder and schizophrenia, and have been related to an impaired neurodevelopment in humans and mice. Here, we have used zebrafish to ... -
Determination of photophysical properties of photoactivatable fluorescent proteins for quantitative super-resolution imaging
(Universitat Politècnica de Catalunya, 2012-09-02)
Master thesis
Open Access[ANGLÈS] This project aims to characterize these photophysical properties such as photobleaching and photoconversion of the photoconvertible fluorescent preotein mEos2 in vitro. It slightly approaches the characterization ... -
Direct Measurement of the Nanomechanical Stability of a Redox Protein Active Site and Its Dependence upon Metal Binding
(ACS Publications, 2015-09-10)
Article
Open AccessThe structural basis of the low reorganization energy of cupredoxins has long been debated. These proteins reconcile a conformationally heterogeneous and exposed metal-chelating site with the highly rigid copper center ... -
Discovery of hit compounds targeting the P4 allosteric site of K-RAS, identified through ensemble-based virtual screening
(American Chemical Society, 2023-10-12)
Article
Open AccessMutants of Ras are oncogenic drivers of a large number of human tumors. Despite being recognized as an attractive target for the treatment of cancer, the high affinity for its substrate tagged the protein as undruggable ... -
Diseño de una planta de producción de un biosimilar de Etanercept
(Universitat Politècnica de Catalunya, 2018-10-31)
Master thesis
Restricted access - author's decisionLa pérdida de los derechos de patente sobre uno de los principios activos superventas de los últimos años, Etanercept – empleado como agente terapéutico contra enfermedades inmunosupresoras como la psoriasis y la artritis ... -
Disseny d'una barra energètica amb alt contingut proteic: proposta de formulació
(Universitat Politècnica de Catalunya, 2022-10-25)
Bachelor thesis
Open AccessAmb l'objectiu de dissenyar un aliment que pugui ser utilitzat com a suplementació esportiva per a practicants d'exercici físic intens, que aporti energia, que suposi una font alta de proteïnes (>20%), i que es pugui ... -
Docosahexaenoic acid phospholipid differentially modulates the conformation of G90V and N55K rhodopsin mutants associated with retinitis pigmentosa
(2017-05-01)
Article
Open AccessRhodopsin is the visual photoreceptor of the retinal rod cells that mediates dim light vision and a prototypical member of the G protein-coupled receptor superfamily. The structural stability and functional performance of ...
