Browsing by Author "Persson, Cecilia"

Now showing items 1-16 of 16

    • A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement 

      Gallinetti, Sara; Mestres, Gemma; Canal Barnils, Cristina; Persson, Cecilia; Ginebra Molins, Maria Pau (Elsevier, 2017-11-01)
      Article
      Open Access
      Covenantee:   Uppsala universitet
      Calcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor toughness limits their use to non-load-bearing applications. Reinforcement through introduction of fibers and yarns has been ...

    • Brushite foams - the effect of Tween® 80 and Pluronic® F-127 on foam porosity and mechanical properties 

      Unosson, Johanna; Montufar Jiménez, Edgar Benjamin; Engqvist, Hakan; Ginebra Molins, Maria Pau; Persson, Cecilia (2015-01-23)
      Article
      Open Access
      Covenantee:   Uppsala universitet
      Resorbable calcium phosphate based bone void fillers should work as temporary templates for new bone formation. The incorporation of macropores with sizes of 100 -300 µm has been shown to increase the resorption rate of ...

    • Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement 

      Mestres Beà, Gemma; Kugiejko, Karol; Pastorino Carraz, David; Unosson, Johanna; Ohman, Caroline; Karlsson Ott, Marjam; Ginebra Molins, Maria Pau; Persson, Cecilia (2016-01-01)
      Article
      Open Access
      Covenantee:   Uppsala universitet
      Calcium phosphate cements are synthetic bone graft substitutes able to set at physiological conditions. They can be applied by minimally invasive surgery and can also be used as drug delivery systems. Consequently, the ...

    • Compressive, diametral tensile and biaxial flexural strength of cutting-edge calcium phosphate cements 

      Luo, Jun; Ajaxon, Ingrid; Ginebra Molins, Maria Pau; Engqvist, Hakan; Persson, Cecilia (Elsevier, 2016-07-01)
      Article
      Open Access
      Covenantee:   Uppsala universitet
      © 2016 The Authors. Calcium phosphate cements (CPCs) are widely used in bone repair. Currently there are two main types of CPCs, brushite and apatite. The aim of this project was to evaluate the mechanical properties of ...

    • Effect of calcium phosphate heparinization on the in vitro inflammatory response and osteoclastogenesis of human blood precursor cells 

      Díez Escudero, Anna; Torreggiani, E.; Pompo, Gemma di; Español Pons, Montserrat; Persson, Cecilia; Ciapetti, Gabriela; Baldini, Nicola; Ginebra Molins, Maria Pau (2019-01-01)
      Article
      Open Access
      Covenantee:   Istituto Ortopedico Rizzoli / Uppsala universitet / Università di Bologna / Institut de Bioenginyeria de Catalunya
      The immobilization of natural molecules on synthetic bone grafts stands as a strategy to enhance their biological interactions. During the early stages of healing, immune cells and osteoclasts (OC) modulate the inflammatory ...

    • Elastic properties and strain-to-crack-initiation of calcium phosphate bone cements: revelations of a high-resolution measurement technique 

      Ajaxon, Ingrid; Acciaioli, A.; Lionello, G.; Ginebra Molins, Maria Pau; Ohman, Caroline; Baleani, M.; Persson, Cecilia (Elsevier, 2017-10-01)
      Article
      Open Access
      Calcium phosphate cements (CPCs) should ideally have mechanical properties similar to those of the bone tissue the material is used to replace or repair. Usually, the compressive strength of the CPCs is reported and, more ...

    • Evaluation of a porosity measurement method for wet calcium phosphate cements 

      Ajaxon, Ingrid; Maazouz, Yassine; Ginebra Molins, Maria Pau; Ohman, Caroline; Persson, Cecilia (2015)
      Article
      Open Access
      Covenantee:   Uppsala universitet
      The porosity of a calcium phosphate cement is a key parameter as it affects several important properties of the cement. However, a successful, non-destructive porosity measurement method that does not include drying has ...

    • Evaluation of bone formation in calcium phosphate scaffolds with mu CT-method validation using SEM 

      Lewin, Susanne; Barba Martí, Antonio; Persson, Cecilia; Franch Serracanta, Jordi; Ginebra Molins, Maria Pau; Ohman, Caroline (2017-12-01)
      Article
      Open Access
      Covenantee:   Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animal
      There is a plethora of calcium phosphate (CaP) scaffolds used as synthetic substitutes to bone grafts. The scaffold performance is often evaluated from the quantity of bone formed within or in direct contact with the ...

    • Functionalized silk promotes cell migration into calcium phosphate cements by providing macropores and cell adhesion motifs 

      Widhe, Mona; Díez Escudero, Anna; Ginebra Molins, Maria Pau; Persson, Cecilia; Hedhammar, My; Mestres, Gemma; Yuling, Liu; Ringström, Nathalie (2022-11-01)
      Article
      Open Access
      Covenantee:   Kungliga Tekniska högskolan / Uppsala universitet / Institut de Bioenginyeria de Catalunya
      Calcium phosphate cements (CPCs) are attractive synthetic bone grafts as they possess osteoconductive and osteoinductive properties. Their biomimetic synthesis grants them an intrinsic nano- and microporosity that resembles ...

    • Heparinization of beta tricalcium phosphate: osteo-immunomodulatory effects 

      Díez Escudero, Anna; Español Pons, Montserrat; Bonany Mariñosa, Mar; Persson, Cecilia; Ginebra Molins, Maria Pau (2018-03-07)
      Article
      Open Access
      Immune cells play a vital role in regulating bone dynamics. This has boosted the interest in developing biomaterials that can modulate both the immune and skeletal systems. In this study, calcium phosphates discs (i.e., ...

    • Impact of biomimicry in the design of osteoinductive bone substitutes: nanoscale matters 

      Barba Serrahima, Albert; Díez Escudero, Anna; Español Pons, Montserrat; Bonany Mariñosa, Mar; Sadowska, Joanna Maria; Guillem Martí, Jordi; Ohman, Caroline; Persson, Cecilia; Manzanares, Maria Cristina; Franch, Jordi; Ginebra Molins, Maria Pau (2019-01-01)
      Article
      Open Access
      Covenantee:   Universitat Autònoma de Barcelona / Uppsala universitet / Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental / Institut de Bioenginyeria de Catalunya
      Bone apatite consists of carbonated calcium-deficient hydroxyapatite (CDHA) nanocrystals. Biomimetic routes allow fabricating synthetic bone grafts that mimic biological apatite. In this work, we explored the role of two ...

    • Inflammatory response to nano- and microstructured hydroxyapatite 

      Mestres, Gemma; Español Pons, Montserrat; xia, wei; Persson, Cecilia; Ginebra Molins, Maria Pau; Karlsson Ott, Marjam (2015-04-02)
      Article
      Open Access
      The proliferation and activation of leukocytes upon contact with a biomaterial play a crucial role in the degree of inflammatory response, which may then determine the clinical failure or success of an implanted biomaterial. ...

    • Osteoinduction by foamed and 3D-printed calcium phosphate scaffolds: effect of nanostructure and pore architecture 

      Barba Serrahima, Albert; Díez Escudero, Anna; Maazouz, Yassine; Rappe, K.; Español Pons, Montserrat; Montufar Jiménez, Edgar Benjamin; Bonany Mariñosa, Mar; Sadowska, Joanna Maria; Guillem Martí, Jordi; Ohman, Caroline; Persson, Cecilia; Manzanares, Maria Cristina; Franch Serracanta, Jordi; Ginebra Molins, Maria Pau (2017-12-06)
      Article
      Open Access
      Covenantee:   Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animal / Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental
      Some biomaterials are osteoinductive, that is, they are able to trigger the osteogenic process by inducing the differentiation of mesenchymal stem cells to the osteogenic lineage. Although the underlying mechanism is still ...

    • Porosity prediction of calcium phosphate cements based on chemical composition 

      Ohman, Caroline; Unusson, Johanna; Carlsson, Elin; Ginebra Molins, Maria Pau; Persson, Cecilia; Engqvist, Hakan (2015-07-01)
      Article
      Open Access
      Covenantee:   Uppsala universitet
      The porosity of calcium phosphate cements has an impact on several important parameters, such as strength, resorbability and bioactivity. A model to predict the porosity for biomedical cements would hence be a useful tool. ...

    • The effect of PCL addition on 3D-printable PLA/HA composite filaments for the treatment of bone defects. 

      Akerlund, Elin; Díez Escudero, Anna; Grzeszczak, Ana; Persson, Cecilia (Multidisciplinary Digital Publishing Institute (MDPI), 2022-08-13)
      Article
      Open Access
      The still-growing field of additive manufacturing (AM), which includes 3D printing, has enabled manufacturing of patient-specific medical devices with high geometrical accuracy in a relatively quick manner. However, the ...

    • The effect of unsaturated fatty acid and triglyceride oil addition on the mechanical and antibacterial properties of acrylic bone cements 

      Persson, Cecilia; Robert, Elise; Carlsson, Elin; Robo, Celine; López-Gil Serra, Alejandro; Ginebra Molins, Maria Pau; Godoy Gallardo, María; Engqvist, Hakan (2015-09-01)
      Article
      Open Access
      Covenantee:   Uppsala universitet
      Acrylic bone cements have an elastic modulus several times higher than the surrounding trabecular bone. This has been hypothesized to contribute to certain clinical complications. There are indications that the addition ...