Now showing items 1-12 of 12

    • A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins 

      Kapp, Tobias G.; Rechenmacher, Florian; Neubauer, Stefanie; Maltsev, Oleg V.; Cavalcanti-Adam, Elisabetta Ada; Zarka, Revital; Reuning, Ute; Notni, Johannes; Wester, Hans-Jürgen; Mas Moruno, Carlos; Spatz, Joachim; Geiger, Benjamin; Kessler, Horst (Macmillan Publishers, 2017-01-11)
      Article
      Open Access
      Covenantee:   Technische Universität München
      Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in ...
    • A molecular toolkit for the functionalization of titanium-based biomaterials that selectively control integrin-mediated cell adhesion 

      Rechenmacher, Florian; Neubauer, Stefanie; Mas Moruno, Carlos (2013-06-06)
      Article
      Restricted access - publisher's policy
      We present a click chemistry- based molecular toolkit for the bio- functionalization of materials to selec- tively control integrin-mediated cell ad- hesion. To this end, a 5 b 1-selective RGD peptidomimetics were ...
    • avß3- or a5ß1-Integrin-Selective Peptidomimetics for Surface Coating 

      Mas Moruno, Carlos; Fraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie; Kapp, Tobias G.; Kessler, Horst (2016-06-13)
      Article
      Open Access
      Covenantee:   Technische Universität München
      Engineering biomaterials with integrin-binding activity is a very powerful approach to promote cell adhesion, modulate cell behavior, and induce specific biological responses at the surface level. The aim of this Review ...
    • Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin avß3-selective cyclic RGD peptides 

      Mas Moruno, Carlos; Dorfner, Petra M.; Manzenrieder, Florian; Neubauer, Stefanie; Reuning, Ute; Burgkart, Rainer; Kessler, Horst (2013)
      Article
      Restricted access - publisher's policy
      It is well known that functionalization of surfaces with cell adhesive peptides mimicking the integrin binding motif of extracellular matrix proteins is a feasible approach to improve osseointegration of implant materials. ...
    • Bioactive compounds immobilized on Ti and TiNbHf: AFM-based investigations of biofunctionalization efficiency and cell adhesion 

      Herranz-Diez, Carolina; Li, Q; Lamprecht, C; Mas Moruno, Carlos; Neubauer, Stefanie; Kessler, Horst; Manero Planella, José María; Guillem Martí, Jordi; Selhuber-Unkel, C (2015)
      Article
      Open Access
      Covenantee:   Technische Universität München
      Implant materials require optimal biointegration, including strong and stable cell-material interactions from the early stages of implantation. Ti-based alloys with low elastic modulus are attracting a lot of interest for ...
    • Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands 

      Fraioli, Roberta; Neubauer, Stefanie; Rechenmacher, Florian; Bosch Canals, Begoña María; Dashnyam, Khandmaa; Kim, Joong-Hyun; Gil Mur, Francisco Javier; Ginebra Molins, Maria Pau; Manero Planella, José María; Mas Moruno, Carlos (Royal Society of Chemistry (RSC), 2019-04-01)
      Article
      Open Access
      Covenantee:   Technische Universität München / Universitat Internacional de Catalunya / Tan'guk Taehakkyo / Institut de Bioenginyeria de Catalunya
      In this communication we report that anchoring avß3 or a5ß1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results ...
    • Functionalizing avß3- or a5ß1-selective integrin antagonists for surface coating: A new tool to discriminate integrin subtypes in vitro 

      Rechenmacher, Florian; Neubauer, Stefanie; Polleux, Julien; Mas Moruno, Carlos; De Simone, Mariarosaria; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim P.; Fässler, Reinhard; Kessler, Horst (2013)
      Article
      Restricted access - publisher's policy
      Thumbnail image of graphical abstract Stuck with the right choice: avß3- or a5ß1-selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured ...
    • Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium 

      Fraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie; Manero Planella, José María; Gil Mur, Francisco Javier; Kessler, Horst; Mas Moruno, Carlos (2015-04-01)
      Article
      Open Access
      Covenantee:   Technische Universität München
      Interaction between the surface of implants and biological tissues is a key aspect of biomaterials research. Apart from fulfilling the non-toxicity and structural requirements, synthetic materials are asked to direct cell ...
    • Novel peptide-based strategies to install osteointegrative properties on metallic biomaterials 

      Fraioli, Roberta; Neubauer, Stefanie; Rechenmacher, Florian; Manero Planella, José María; Kessler, Horst; Gil Mur, Francisco Javier; Mas Moruno, Carlos (2015)
      Conference lecture
      Open Access
      Covenantee:   Technische Universität München
    • Pharmacophoric modifications lead to superpotent avß3 integrin ligands with suppressed a5ß1 activity 

      Neubauer, Stefanie; Rechenmacher, Florian; Brimioulle, Richard; Di Leva, Francisco Saverio; Bochen, Alexander; Sobahi, Tariq R.; Schottelius, Margret; Novellino, Ettore; Mas Moruno, Carlos; Marinelli, Luciana; Kessler, Horst (2014-04-24)
      Article
      Restricted access - publisher's policy
      Covenantee:   Technische Universität München
      The selective targeting of the avß3 integrin subtype without affecting the structurally closely related receptor a5ß1 is crucial for understanding the details of their biological and pathological functions and thus of great ...
    • The integrin ligand c(RGDf(NMe)Nal) reduces neointimal hyperplasia in a polymer-free drug-eluting stent system 

      Rechenmacher, Florian; Steigerwald, Kristin; Laufer, Burkhardt; Neubauer, Stefanie; Kapp, Tobias G.; Li, Liang; Mas Moruno, Carlos; Joner, Michael; Kessler, Horst (2014-07-01)
      Article
      Restricted access - publisher's policy
      Covenantee:   Technische Universität München / Deutsches Herzzentrum München / CVPath Institute
      The use of highly active and selective integrin ligands in combination with stent implantation is emerging as a promising alternative to the release of classical immunosuppressive drugs by current drug-eluting stents (DES), ...
    • Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands 

      Fraioli, Roberta; Tsimbouri, Penelope M.; Fisher, Leanne E.; Nobbs, Angela H.; Su, Bo; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Ginebra Molins, Maria Pau; Dalby, Matthew J.; Manero Planella, José María; Mas Moruno, Carlos (Macmillan Publishers, 2017-11-27)
      Article
      Open Access
      Covenantee:   Technische Universität München / University of Bristol. Bristol Dental School
      Engineering the interface between biomaterials and tissues is important to increase implant lifetime and avoid failures and revision surgeries. Permanent devices should enhance attachment and differentiation of stem cells, ...