Now showing items 1-3 of 3

  • Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network 

    Capasso, Serena; Sticco, Lucia; Rizzo, Riccardo; Pirozzi, Marinella; Russo, Domenico; Dathan, Nina A.; Campelo, Felix; Galen, Josse van; Hölttä-Vuori, Maarit; Turacchio, Gabriele; Hausser, Angelika; Malhotra, Vivek; Riezman, Isabelle; Riezman, Howard; Ikonen, Elina; Luberto, Chiara; Parashuraman, Seetharaman; Luini, Alberto; Angelo, Giovanni D (Embo press, 2017-04-10)
    Article
    Open Access
    Sphingolipids are membrane lipids, which are globally required for eukaryotic life. Sphingolipid composition varies among endomembranes with pre- and post-Golgi compartments being poor and rich in sphingolipids, respectively. ...
  • Sphingomyelin metabolism controls the shape and function of the Golgi cisternae 

    Campelo, Felix; Galen, Josse van; Turacchio, Gabriele; Parashuraman, Seetharaman; Kozlov, Michael M.; Garcia-Parajo, Maria F.; Malhotra, Vivek (eLife Sciences Publications, 2017-05-13)
    Article
    Open Access
    The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us ...
  • TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes 

    Raote, Ishier; Ortega-Bellido, María; Santos, António J M; Foresti, Ombretta; Zhang, Chong; Garcia-Parajo, Maria F; Campelo, Felix; Malhotra, Vivek (eLife Sciences Publications, 2018-03-07)
    Article
    Open Access
    Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky ...