Now showing items 1-3 of 3

    • Mapping the Long-Range Electron Transfer Route in Ligninolytic Peroxidases 

      Acebes, Sandra; Ruiz-Dueñas, Francisco J.; Toubes, Mario; Sáez-Jiménez, Veronica; Pérez-Boada, Marta; Lucas, M. Fatima; Martínez, Angel T.; Guallar, Victor (ACS Publications, 2017-04-04)
      Article
      Open Access
      Combining a computational analysis with site-directed mutagenesis, we have studied the long-range electron transfer pathway in versatile and lignin peroxidases, two enzymes of biotechnological interest that play a key role ...
    • Repurposing designed mutants: a valuable strategy for computer-aided laccase engineering – the case of POXA1b 

      Giacobelli, Valerio G.; Monza, Emanuele; Lucas, M. Fatima; Pezzella, Cinzia; Piscitelli, Alessandra; Guallar, Victor; Sannia, Giovanni (Royal Society of Chemistry, 2017-01-04)
      Article
      Open Access
      The broad specificity of laccases, a direct consequence of their shallow binding site, makes this class of enzymes a suitable template to build specificity toward putative substrates. In this work, a computational methodology ...
    • Simulating Substrate Recognition and Oxidation in Laccases: From Description to Design 

      Lucas, M. Fatima; Monza, Emanuele; Jorgensen, Lise J.; Ernst, Heidi A.; Piontek, Klaus; Bjerrum, Morten J.; Martinez, Angel T.; Camarero, Susana; Guallar, Victor (2017-02-10)
      Article
      Open Access
      To meet the very specific requirements demanded by industry, proteins must be appropriately tailored. Engineering laccases, to improve the oxidation of small molecules, with applications in multiple fields, is, however, a ...