Browsing by Author "Ksiezopolska, Ewa"
Now showing items 1-7 of 7
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Benzylic Dehydroxylation of Echinocandin antifungal drugs restores efficacy against resistance conferred by mutated Glucan Synthase
(American Chemical Society (ACS), 2022-03)
Article
Open AccessEach year, infections caused by fungal pathogens claim the lives of about 1.6 million people and affect the health of over a billion people worldwide. Among the most recently developed antifungal drugs are the echinocandins, ... -
Chromosome-level assemblies from diverse clades reveal limited structural and gene content variation in the genome of Candida glabrata
(BioMed Central (BMC), 2022)
Article
Open AccessBackground Candida glabrata is an opportunistic yeast pathogen thought to have a large genetic and phenotypic diversity and a highly plastic genome. However, the lack of chromosome-level genome assemblies representing ... -
Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors
(Nature Research, 2022)
Article
Open AccessThe relevance of the human oral microbiome to our understanding of human health has grown in recent years as microbiome studies continue to develop. Given the links of the oral cavity with the digestive, respiratory and ... -
Elevated vacuolar uptake of fluorescently labeled antifungal drug caspofungin predicts echinocandin resistance in pathogenic yeast
(American Chemical Society, 2020)
Article
Open AccessEchinocandins are the newest class of antifungal drugs in clinical use. These agents inhibit β-glucan synthase, which catalyzes the synthesis of β-glucan, an essential component of the fungal cell wall, and have a high ... -
Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata
(Elsevier, 2021)
Article
Open AccessFungal infections are a growing medical concern, in part due to increased resistance to one or multiple antifungal drugs. However, the evolutionary processes underpinning the acquisition of antifungal drug resistance are ... -
Oral microbiome in down syndrome and its implications on oral health
(Taylor and Francis, 2020)
Article
Open AccessIntroduction: The oral cavity harbors an abundant and diverse microbial community (i.e. the microbiome), whose composition and roles in health and disease have been the focus of intense research. Down syndrome (DS) is ... -
The transcriptional aftermath in two independently formed hybrids of the opportunistic pathogen candida orthopsilosis
(American Society for Microbiology, 2020)
Article
Open AccessInterspecific hybridization can drive evolutionary adaptation to novel environments. The Saccharomycotina clade of budding yeasts includes many hybrid lineages, and hybridization has been proposed as a source for new ...
