Now showing items 1-5 of 5

    • Atomic force microscopy-based mechanobiology 

      Krieg, Michael; Fläschner, Gotthold; Alsteens, David; Gaub, Benjamin M.; Roos, Wouter H.; Wuite, Gijs J. L.; Gaub, Hermann E.; Gerber, Christoph; Dufrêne, Yves F; Mülle, Daniel J. (Nature, 2018-11-01)
      Article
      Open Access
      Mechanobiology emerges at the crossroads of medicine, biology, biophysics and engineering and describes how the responses of proteins, cells, tissues and organs to mechanical cues contribute to development, differentiation, ...
    • Direct force measurements of subcellular mechanics in confinement using optical tweezers 

      Català Castro, Frederic; Venturini, Valeria; Ruprecht, Verena; Krieg, Michael (2021-08-31)
      Article
      Open Access
      During the development of a multicellular organism, a single fertilized cell divides and gives rise to multiple tissues with diverse functions. Tissue morphogenesis goes in hand with molecular and structural changes at the ...
    • Neuronal stretch reception – making sense of the mechanosense 

      Das, Ravi; Wieser, Stefan; Krieg, Michael (Elsevier, 2019-05-01)
      Article
      Open Access
      The sensation of mechanical force underlies many of our daily activities. As the sense of touch determines the quality of life, the subconscious sense of proprioception and visceral mechanosensation is indispensible for ...
    • Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation 

      Cabré, Gisela; Garrido-Charle, Aida; Moreno, Miquel; Bosch, Miquel; Porta-de-la-Riva, Montserrat; Krieg, Michael; Gascón-Moya, Marta; Camarero, Núria; Gelabert, Ricard; Lluch, José M.; Busqué, Félix; Hernando, Jordi; Gorostiza, Pau; Alibés, Ramon (Nature, 2019-02-22)
      Article
      Open Access
      Manipulation of neuronal activity using two-photon excitation of azobenzene photoswitches with near-infrared light has been recently demonstrated, but their practical use in neuronal tissue to photostimulate individual ...
    • The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior 

      Venturini, Valeria; Pezzano, Fabio; Català Castro, Frederic; Häkkinen, Hanna-Maria; Jiménez-Delgado, Senda; Colomer Rosell, Mariona; Marro, Monica; Tolosa-Ramon, Queralt; Paz-López, Sonia; Valverde, Miguel A.; Weghuber, Julian; Loza- Alvarez, Pablo; Krieg, Michael; Wieser, Stefan; Ruprecht, Verena (ACS, 2020-10-16)
      Article
      Open Access
      Single cells continuously experience and react to mechanical challenges in three-dimensional tissues. Spatial constraints in dense tissues, physical activity, and injury all impose changes in cell shape. How cells can ...