Browsing by Author "Kim, Kyungman"

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Non-constant hazard ratios in randomized controlled trials with composite endpoints

Cortés Martínez, Jordi; Gómez Mateu, Moisès; Kim, Kyungman; Gómez Melis, Guadalupe (2019-07-25)
Article
Open Access
The hazard ratio is routinely used as a summary measure to assess the treatment effect in clinical trials with time-to-event endpoints. It is frequently assumed as constant over time although this assumption often does not ...
Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

Cortés Martínez, Jordi; Geskus, Ronald; Kim, Kyungman; Gómez Melis, Guadalupe (2021-05-06)
Article
Open Access
Background: Sample size calculation is a key point in the design of a randomized controlled trial. With time-to-event outcomes, it’s often based on the logrank test. We provide a sample size calculation method for a composite ...