Browsing by Author "Kim, Kyungman"
Cortés Martínez, Jordi; Gómez Mateu, Moisès; Kim, Kyungman; Gómez Melis, Guadalupe (2019-07-25)
Open AccessThe hazard ratio is routinely used as a summary measure to assess the treatment effect in clinical trials with time-to-event endpoints. It is frequently assumed as constant over time although this assumption often does not ...
Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints Cortés Martínez, Jordi; Geskus, Ronald; Kim, Kyungman; Gómez Melis, Guadalupe (2021-05-06)
Open AccessBackground: Sample size calculation is a key point in the design of a randomized controlled trial. With time-to-event outcomes, it’s often based on the logrank test. We provide a sample size calculation method for a composite ...