Browsing by Author "Henriet, Theo"

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    • Solid state stability and solubility of triethylenetetramine dihydrochloride 

      Henriet, Theo; Gana, Inès; Ghaddar, Carine; Barrio Casado, María del; Cartigny, Yohann; Yagoubi, Najet; Do, Bernard; Tamarit Mur, José Luis; Rietveld, Ivo B. (2016-09-10)
      Article
      Open Access
      The API triethylenetetramine dihydrochloride used as an alternative treatment of Wilson¿s disease is sensitive to water and it exhibits polymorphism. As this may become an issue for the drug formulation, the physical ...

    • Triethylenetetramine dihydrochloride: interactions and conformations in two anhydrous structures and a hydrate 

      Henriet, Theo; Nicolai, Beatrice; Ghaddar, Carine; Barrio Casado, María del; Do, Bernard; Yagoubi, Najet; Tamarit Mur, José Luis; Rietveld, Ivo B. (2015-01-01)
      Article
      Open Access
      Triethylenetetramine is a polyamine type chelating ligand for copper(II), which is currently used, mainly in its dihydrochloride form, as an alternative to d-penicillamine against Wilsons disease. Because knowledge about ...