Now showing items 1-3 of 3

  • An integrated view of theiInfluence of temperature, pressure, and humidity on the stability of trimorphic cysteamine hydrochloride 

    Gana, Inès; Barrio Casado, María del; Ghaddar, Carine; Nicolai, Beatrice; Do, Bernard; Tamarit Mur, José Luis; Safta, Fathi; Rietveld, Ivo B. (2015-07-01)
    Article
    Open Access
    Understanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after the incident with ritonavir. In the present paper, a comprehensive study of the ...
  • Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III 

    Gana, Inès; Barrio Casado, María del; Do, Bernard; Tamarit Mur, José Luis; Céolin, René; Rietveld, Ivo B. (2013-11-18)
    Article
    Restricted access - publisher's policy
    tUnderstanding the phase behavior of an active pharmaceutical ingredient in a drug formulation isrequired to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in amarketed product. ...
  • Solid state stability and solubility of triethylenetetramine dihydrochloride 

    Henriet, Theo; Gana, Inès; Ghaddar, Carine; Barrio Casado, María del; Cartigny, Yohann; Yagoubi, Najet; Do, Bernard; Tamarit Mur, José Luis; Rietveld, Ivo B. (2016-09-10)
    Article
    Open Access
    The API triethylenetetramine dihydrochloride used as an alternative treatment of Wilson¿s disease is sensitive to water and it exhibits polymorphism. As this may become an issue for the drug formulation, the physical ...