Now showing items 1-3 of 3

    • An integrated view of theiInfluence of temperature, pressure, and humidity on the stability of trimorphic cysteamine hydrochloride 

      Gana, Inès; Barrio Casado, María del; Ghaddar, Carine; Nicolai, Beatrice; Do, Bernard; Tamarit Mur, José Luis; Safta, Fathi; Rietveld, Ivo B. (2015-07-01)
      Article
      Open Access
      Understanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after the incident with ritonavir. In the present paper, a comprehensive study of the ...
    • Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III 

      Gana, Inès; Barrio Casado, María del; Do, Bernard; Tamarit Mur, José Luis; Céolin, René; Rietveld, Ivo B. (2013-11-18)
      Article
      Restricted access - publisher's policy
      tUnderstanding the phase behavior of an active pharmaceutical ingredient in a drug formulation isrequired to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in amarketed product. ...
    • Solid state stability and solubility of triethylenetetramine dihydrochloride 

      Henriet, Theo; Gana, Inès; Ghaddar, Carine; Barrio Casado, María del; Cartigny, Yohann; Yagoubi, Najet; Do, Bernard; Tamarit Mur, José Luis; Rietveld, Ivo B. (2016-09-10)
      Article
      Open Access
      The API triethylenetetramine dihydrochloride used as an alternative treatment of Wilson¿s disease is sensitive to water and it exhibits polymorphism. As this may become an issue for the drug formulation, the physical ...