Browsing by Author "Gabaldón, Toni"
Now showing items 1-20 of 32
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A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome
(MDPI, 2021)
Article
Open AccessHeart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of either the cardiac ventricular filling, ejection of blood capacity or ... -
Aspergillus fumigatus and aspergillosis: From basics to clinics
(Elsevier, 2021)
Article
Open AccessThe airborne fungus Aspergillus fumigatus poses a serious health threat to humans by causing numerous invasive infections and a notable mortality in humans, especially in immunocompromised patients. Mould-active azoles are ... -
Benzylic Dehydroxylation of Echinocandin antifungal drugs restores efficacy against resistance conferred by mutated Glucan Synthase
(American Chemical Society (ACS), 2022-03)
Article
Open AccessEach year, infections caused by fungal pathogens claim the lives of about 1.6 million people and affect the health of over a billion people worldwide. Among the most recently developed antifungal drugs are the echinocandins, ... -
Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells
(Springer Nature, 2021)
Article
Open AccessVaginal candidiasis is an extremely common disease predominantly caused by four phylogenetically diverse species: Candida albicans; Candida glabrata; Candida parapsilosis; and Candida tropicalis. Using a time course infection ... -
Chromatin profiling reveals heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus
(Public Library of Science, 2022-01)
Article
Open AccessInvasive Pulmonary Aspergillosis, which is caused by the filamentous fungus Aspergillus fumigatus, is a life-threatening infection for immunosuppressed patients. Chromatin structure regulation is important for genome ... -
Chromosome-level assembly, annotation and phylome of Pelobates cultripes, the western spadefoot toad
(Oxford University Press, 2022-06)
Article
Open AccessGenomic resources for amphibians are still hugely under-represented in vertebrate genomic research, despite being a group of major interest for ecology, evolution and conservation. Amphibians constitute a highly threatened ... -
Comparative genomic analysis of clinical Candida glabrata isolates identifies multiple polymorphic loci that can improve existing multilocus sequence typing strategy
(Elsevier, 2021)
Article
Open AccessCandida glabrata is the second leading cause of candidemia in many countries and is one of the most concerning yeast species of nosocomial importance due to its increasing rate of antifungal drug resistance and emerging ... -
Examination of Genome-Wide Ortholog variation in clinical and environmental isolates of the fungal pathogen Aspergillus fumigatus
(American Society for Microbiology, 2022-06-29)
Article
Open AccessAspergillus fumigatus is a cosmopolitan species of fungus responsible for thousands of cases of invasive disease annually. Clinical and environmental isolates of A. fumigatus exhibit extensive phenotypic differences, ... -
Fungal evolution: cellular, genomic and metabolic complexity
(Wiley, 2020-10)
Article
Open AccessThe question of how phenotypic and genomic complexity are inter‐related and how they are shaped through evolution is a central question in biology that historically has been approached from the perspective of animals and ... -
Genome analysis of Candida subhashii reveals its hybrid nature and dual mitochondrial genome conformations
(Oxford University Press, 2021-06)
Article
Open AccessCandida subhashii belongs to the CUG-Ser clade, a group of phylogenetically closely related yeast species that includes some human opportunistic pathogens, such as Candida albicans. Despite being present in the environment, ... -
Genome analysis of five recently described species of the CUG-Ser clade uncovers Candida theae as a new hybrid lineage with pathogenic potential in the Candida parapsilosis species complex
(Oxford University Press, 2022-04)
Article
Open AccessCandida parapsilosis species complex comprises three important pathogenic species: Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis. The majority of C. orthopsilosis and all C. metapsilosis ... -
Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans
(BioMed Central, 2020)
Article
Open Access -
Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells
(Public Library of Science (PLoS), 2021)
Article
Open AccessThe opportunistic pathogen Candida glabrata is the second most frequent causative agent of vulvovaginal candidiasis (VVC), a disease that affects 70–75% of women at least once during their life. However, C. glabrata is ... -
Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins
(Oxford University Press, 2021-07)
Article
Open AccessThe modification of adenosine to inosine at the wobble position (I34) of tRNA anticodons is an abundant and essential feature of eukaryotic tRNAs. The expansion of inosine-containing tRNAs in eukaryotes followed the ... -
Hybridization and the origin of new yeast lineages
(Oxford University Press (OUP), 2020-08)
Article
Open AccessHybrids originate from the mating of two diverged organisms, resulting in novel lineages that have chimeric genomes. Hybrids may exhibit unique phenotypic traits that are not necessarily intermediate between those present ... -
Improving trimAl ability to cope with heterogeneous multiple sequence alignments
(Barcelona Supercomputing Center, 2018-04-24)
Conference report
Open Access -
Multiple hybridization events punctuate the evolutionary trajectory of malassezia furfur
(American Society for Microbiology, 2022)
Article
Open AccessMalassezia species are important fungal skin commensals and are part of the normal microbiota of humans and other animals. However, under certain circumstances these fungi can also display a pathogenic behavior. For example, ... -
On the Biology, Diversity and Evolution of Nucleariid Amoebae (Amorphea, Obazoa, Opisthokonta
(Elsevier, 2022-06)
Article
Open AccessNucleariids are a small group of free-living heterotrophic amoebae. Although these organisms present a variety of cell sizes and cell coverings, they are mostly spherical cells with radiating filopodia, sometimes with ... -
PerSVade: personalized structural variation detection in your species of interest
(Barcelona Supercomputing Center, 2021-05)
Conference report
Open AccessStructural variants (SV) such as translocations, inversions, deletions, and other genomic rearrangements can contribute significantly to genetic and phenotypic variability across many species. The role of SV has been ... -
Phenotypic Variability in a Coinfection With Three Independent Candida parapsilosis Lineages
(Frontiers Media, 2020-08)
Article
Open AccessThe human pathogenic yeast Candida parapsilosis has gained significant importance over the past decades as one of the principal causes of fungal bloodstream infections. Isolates of C. parapsilosis are known to be able to ...
