Now showing items 1-13 of 13

    • 5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study 

      de la Torre, Rafael; Martín-Santos, Rocío; Torrens, M.; Poudevida, Sandra; Langohr, Klaus; Cuyas, Elisabet; Pacifici, Roberta; Farré, Magí; Pichini, Simona (2010-01)
      Article
      Restricted access - publisher's policy
      A 3-year longitudinal prospective study was conducted to compare the incidence of substance use disorders (SUD) and non-substance use disorders (NSUD) among ecstasy users and two control groups: one of cannabis users and ...
    • A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials 

      de Sola Llopis, Susana; De la Torre Fornell, Rafael; Sánchez Benavides, Gonzalo; Benejam, Bessy; Cuenca, Aída; del Hoyo, Laura; Rodríguez, Joan; Catuara-Solarz, Silvina; Sánchez-Gutiérrez, Judit; Dueñas-Espín, Ivan; Hernández, Gimena; Peña-Casanovas, Jordi; Langohr, Klaus; Videla, Sebastià; Blehaut, Henri; Farré, Magí; Dierssen, Mara (2015-06-04)
      Article
      Open Access
      The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological ...
    • A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome 

      De la Torre Fornell, Rafael; de Sola Llopis, Susana; Farré, Magí; Xicota, Laura; Cuenca Royo, Aida; Langohr, Klaus (2020-02-01)
      Article
      Open Access
    • Altered brain functional connectivity in relation to perception of scrutiny in social anxiety disorder 

      Gimenez, Monica; Pujol Nuez, Jesus; Ortiz Valencia, Héctor; Soriano-Mas, Carles; López Solà, Marina; Farré, Magí; Deus Yela, Joan; Merlo-Pich, Emilio; Martín-Santos, Rocío (2012-06-30)
      Article
      Restricted access - publisher's policy
      Although the fear of being scrutinized by others in a social context is a key symptom in social anxiety disorder (SAD), the neural processes underlying the perception of scrutiny have not previously been studied by ...
    • Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy''): the influence of gender and genetics (CYP2D6, COMT, 5-HTT) 

      Pardo-Lozano, Ricardo; Farré, Magí; Yubero-Lahoz, Samanta; O’Mathúna, Brian; Torrens, M.; Mustata, Cristina; Pérez-Mañá, Clara; Langohr, Klaus; Cuyàs, Elisabet; Carbó, Marcel·lí; de la Torre, Rafael (2012-10-24)
      Article
      Open Access
      The synthetic psychostimulant MDMA (63,4-methylenedioxymethamphetamine, ecstasy) acts as an indirect serotonin, dopamine, and norepinephrine agonist and as a mechanism-based inhibitor of the cytochrome P-450 2D6 (CYP2D6). ...
    • Ethanol induces hydroxytyrosol formation in humans 

      Pérez-Mañá, Clara; Farré, Magí; Pujadas, Mitona; Mustata, Cristina; Menoyo, Ester; Pastor, Antoni; Langohr, Klaus; De la Torre Fornell, Rafael (2015)
      Article
      Open Access
      Previous studies in animals have shown an increase of hydroxytyrosol (OHTyr), a potent phenolic antioxidant and a minor metabolite of dopamine (also called 3,4-dihydroxyphenylethanol or DOPET), after ethanol intake. The ...
    • Non-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol 

      Pérez-Mañá, Clara; Farré, Magí; Pastor, Antoni; Fonseca, Francina; Torrens, Marta; Menoyo, Ester; Pujadas, Mitona; Frias, Silvia; Langohr, Klaus; De la Torre Fornell, Rafael (2017-09-01)
      Article
      Open Access
      Aims Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The ...
    • Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism 

      Goday Arno, Albert; Farré, Magí; Rodriguez Morato, Jose; Ramon, Jose M.; Perez Maña, Clara; Papaseit, Esther; Civit, Ester; Langohr, Klaus; Li Carbo, Marcel; De la Torre Fornell, Rafael (2017-05-30)
      Article
      Open Access
      The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). In ...
    • Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial 

      De la Torre Fornell, Rafael; de Sola Llopis, Susana; Hernández, Gimena; Farré, Magí; Langohr, Klaus; Cuenca Royo, Aida; Xicota, Laura; Janel, Nathalie; Sanchez Benavides, Gonzalo; Blehaut, Henri; del Hoyo, Laura; Benejam, Bessy; Blanco Hinojo, Laura; Videla, Sebastià; Dierssen, Mara (2016-07-01)
      Article
      Open Access
      Background Early cognitive intervention is the only routine therapeutic approach used for amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are limited. We hypothesised that ...
    • Semantic verbal fluency pattern, dementia rating scores and adaptive behavior correlate with plasma Aß42 concentrations in down syndrome young adults 

      del Hoyo, Laura; Xicota, Laura; Sánchez Benavides, Gonzalo; Cuenca Royo, Aida; de Sola Llopis, Susana; Langohr, Klaus; Fagundo, Ana Beatriz; Farré, Magí; Dierssen, Mara; De la Torre Fornell, Rafael (2015-11-18)
      Article
      Open Access
      © 2015 Del Hoyo, Xicota, Sánchez-Benavides, Cuenca-Royo, de Sola, Langohr, Fagundo, Farre, Dierssen and de La Torre. Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal ...
    • The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users 

      Fagundo, Ana B.; Cuyas, Elisabet; Verdejo Garcia, Antonio; Khymenets, Olha; Langohr, Klaus; Martín-Santos, Rocío; Farré, Magí; de la Torre, Rafael (2010-09)
      Article
      Restricted access - publisher's policy
      Deficits in verbal fluency associated with ecstasy use have been well established; however, the mechanisms underlying this impairment have yet to be elucidated. In this study we investigated for the first time whether there ...
    • The tryptophan system in cocaine-induced depression 

      Fonseca, Francina; Mestre Pintó, Joan; Gómez Gómez, Àlex; Langohr, Klaus; Pozo, Oscar; Farré, Magí; Torrens, Marta (Multidisciplinary Digital Publishing Institute (MDPI), 2020-12-19)
      Article
      Open Access
      Major depression disorder (MDD) is the most prevalent psychiatric comorbid condition in cocaine use disorder (CUD). The comorbid MDD might be primary-MDD (CUD-primary-MDD) or cocaine-induced MDD (CUD-induced-MDD), and their ...
    • VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome 

      del Hoyo, Laura; Xicota, Laura; Langohr, Klaus; Sánchez Benavides, Gonzalo; de Sola Llopis, Susana; Cuenca Royo, Aida; Rodríguez, Joan; Farré, Magí; Dierssen, Mara; de la Torre, Rafael (2016-10-17)
      Article
      Open Access
      Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior ...