Now showing items 1-3 of 3

    • A new intermediate polymorph of 1-fluoro-adamantane and its second-order-like transition toward the low temperature phase 

      Yuan, Lina; Clevers, Simon; Burel, Antoine; Negrier, Philippe; Barrio Casado, María del; Ben Hassine, Bacem; Mondieig, Denise; Dupray, Valérie; Tamarit Mur, José Luis; Coquerel, Gerard (2017-06-07)
      Article
      Open Access
      Phase transitions of 1-fluoro-adamantane have been thoroughly investigated by temperature-resolved second harmonic generation (TR-SHG) and X-ray powder diffraction (XRPD). A new polymorph - an intermediate centrosymmetric ...
    • Does the trihydrate of atorvastatin calcium possess a melting point? 

      Barrio Casado, María del; Clevers, Simon; Dupray, Valérie; Coquerel, Gerard; Tamarit Mur, José Luis; Rietveld, Ivo B. (2020-05-30)
      Article
      Open Access
      To decide whether an active pharmaceutical ingredient can be used in its amorphous form in drug formulations, often the glass transition is studied in relation to the melting point of the pharmaceutical. If the glass ...
    • Enhancement of the physical and chemical stability of amorphous drug-polymer mixtures via cryogenic comilling 

      Romanini, Michela; Lorente, Marta; Schammé, Benjamin; Delbreilh, Laurent; Dupray, Valérie; Coquerel, Gerard; Tamarit Mur, José Luis; Macovez, Roberto (American Chemical Society (ACS), 2018-11-27)
      Article
      Open Access
      Amorphous dispersions of the Biclotymol antiseptic are obtained in polyvinylpyrrolidone (PVP), for different drug loadings, by comilling at temperatures below the glass transition of both components. Characterization of ...