Browsing by Author "De la Torre Fornell, Rafael"
Now showing items 1-12 of 12
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A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
(2015-06-04)
Article
Open AccessThe recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological ... -
Active transmembrane drug transport in microgravity: A validation study using an ABC transporter model
(2014-12-11)
Article
Open AccessMicrogravity has been shown to influence the expression of ABC (ATP-Binding Cassette) transporters in bacteria, fungi and mammals, but also to modify the activity of certain cellular components with structural and functional ... -
Data on the endogenous conversion of tyrosolinto hydroxytyrosol in humans
(Elsevier, 2019-12)
Article
Open AccessHere we present new and original data on the endogenous con-version of tyrosol (Tyr) into hydroxytyrosol (OHTyr) in humans and its effects on the cardiovascular system. A randomized,crossover, controlled clinical trial was ... -
Ethanol induces hydroxytyrosol formation in humans
(2015)
Article
Open AccessPrevious studies in animals have shown an increase of hydroxytyrosol (OHTyr), a potent phenolic antioxidant and a minor metabolite of dopamine (also called 3,4-dihydroxyphenylethanol or DOPET), after ethanol intake. The ... -
N-of-1 clinical trials in nutritional interventions directed at improving cognitive function
(2019-07-23)
Article
Open AccessLonger life expectancy has led to an increase in the prevalence of age-related cognitive decline and dementia worldwide. Due to the current lack of effective treatment for these conditions, preventive strategies represent ... -
Non-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol
(2017-09-01)
Article
Open AccessAims Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The ... -
Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism
(2017-05-30)
Article
Open AccessThe purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). In ... -
Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
(2016-07-01)
Article
Open AccessBackground Early cognitive intervention is the only routine therapeutic approach used for amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are limited. We hypothesised that ... -
Semantic verbal fluency pattern, dementia rating scores and adaptive behavior correlate with plasma Aß42 concentrations in down syndrome young adults
(2015-11-18)
Article
Open Access© 2015 Del Hoyo, Xicota, Sánchez-Benavides, Cuenca-Royo, de Sola, Langohr, Fagundo, Farre, Dierssen and de La Torre. Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal ... -
Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity
(Nature, 2019-12-01)
Article
Open AccessMorbid obesity and bariatric surgery induce anatomical, physiological and metabolic alterations that may alter the body’s disposition of drugs. Current literature on this topic is limited and sometimes inconsistent. ...
