Browsing by Author "De Koning, Harry Pieter"
Now showing items 1-3 of 3
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Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast
(2017-08-21)
Article
Open AccessTrypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of ... -
In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27
(2014-06)
Article
Open AccessThe DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies ... -
New drugs complexed with AT-rich DNA against neglected diseases
(2019)
Conference lecture
Restricted access - publisher's policy
