Now showing items 1-3 of 3

    • Asymmetric sulfoxidation by engineering the heme pocket of a dye-decolorizing peroxidase 

      Linde, Dolores; Cañellas, Marina; Coscolín, Cristina; Davó-Siguero, Irene; Romero, Antonio; Lucas, Fátima; Ruiz-Dueñas, Francisco J.; Guallar, Víctor; Martínez, Ángel T. (Royal Society of Chemistry, 2016-05-23)
      Article
      Open Access
      The so-called dye-decolorizing peroxidases (DyPs) constitute a new family of proteins exhibiting remarkable stability. With the aim of providing them new catalytic activities of biotechnological interest, the heme pocket ...
    • Controlled manipulation of enzyme specificity through immobilization-induced flexibility constraints 

      Coscolín, Cristina; Beloqui, Ana; Martínez-Martínez, Mónica; Bargiela, Rafael; Santiago, Gerard; Blanco, Rosa M.; Delaittre, Guillaume; Márquez-Álvarez, Carlos; Ferrer, Manuel (Elsevier, 2018-09-05)
      Article
      Open Access
      It is thought that during immobilization enzymes, as dynamic biomolecules, may become distorted and this may alter their catalytic properties. However, the effects of different immobilization strategies on enzyme rigidity ...
    • Rational Engineering of Multiple Active Sites in an Ester Hydrolase 

      Santiago, Gerard; Martínez-Martínez, Mónica; Alonso, Sandra; Bargiela, Rafael; Coscolín, Cristina; Golyshing, Peter N.; Guallar, Victor; Ferrer, Manuel (American Chemical Society, 2018-03-30)
      Article
      Open Access
      Effects of altering the properties of an active site in an enzymatic homogeneous catalyst have been extensively reported. However, the possibility of increasing the number of such sites, as commonly done in heterogeneous ...