Now showing items 1-11 of 11

    • A 3D finite element model of ventral furrow invagination in the Drosophila melanogaster embryo 

      Conte, Vito; Muñoz Romero, José; Miodownik, Mark (2008-04)
      Article
      Open Access
      The paper describes a mechanical model of epithelial tissue development in Drosophila embryos to investigate a buckling phenomenon called invagination. The finite element method is used to model this ventral furrow formation ...
    • A biomechanical analysis of ventral furrow formation in the Drosophila melanogaster embryo 

      Conte, Vito; Ulrich, Florian; Baum, Buzz; Muñoz Romero, José; Veldhuis, Jim; Brodland, Wayne; Miodownik, M. (2012-03-28)
      Article
      Open Access
      The article provides a biomechanical analysis of ventral furrow formation in the Drosophila melanogaster embryo. Ventral furrow formation is the first large-scale morphogenetic movement in the fly embryo. It involves ...
    • A truss element for modelling reversible softening in living tissues 

      Muñoz Romero, José; Conte, Vito; Asadipour, Nina; Miodownik, M. (2013-04-01)
      Article
      Open Access
      We resort to non-linear viscoelasticity to develop a truss element able to model reversible softening in lung epithelial tissues undergoing transient stretch. Such a Maxwell truss element is built by resorting to a ...
    • Collective cell durotaxis emerges from long-range intercellular force transmission 

      Sunyer, Raimon; Conte, Vito; Escribano, Jorge; Elosegui Artola, Alberto; Labernadie, Anna; Valon, Leo; Navajas Navarro, Daniel; Garcia Aznar, José Manuel; Muñoz Romero, José; Trepat, Xavier (2016-09-09)
      Article
      Open Access
      The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated ...
    • Computation of forces from deformed visco-elastic biological tissues 

      Muñoz Romero, José; Amat Olóndriz, David; Conte, Vito (2018-04-01)
      Article
      Open Access
      We present a least-squares based inverse analysis of visco-elastic biological tissues. The proposed method computes the set of contractile forces (dipoles) at the cell boundaries that induce the observed and quantified ...
    • Computational tools for multicellular systems 

      Muñoz Primer, Jose J.; Mosaffa, Payman; Asadipour, Nina; Conte, Vito (EUETIB, 2014-12-01)
      Conference report
      Open Access
      Macroscopic deformations in embryonic soft tissues are due to the intra-cellular remodelling and cell intercalation. We here present a computational approach that can handle the two types of deformations, and also take ...
    • Control of cell-cell forces and collective cell dynamics by the intercellular adhesome 

      Bazellieres, Elsa; Conte, Vito; Elosegui Artola, Alberto; Serra-Picamal, Xavier; Bintanel Morcillo, Maria; Roca Cusachs, Pere; Muñoz Romero, José; Sales Pardo, Marta; Guimerà, Roger; Trepat Guixer, Xavier (2015-04-01)
      Article
      Open Access
      Dynamics of epithelial tissues determine key processes in development, tissue healing and cancer invasion. These processes are critically influenced by cell-cell adhesion forces. However, the identity of the proteins that ...
    • Mapping forces and kinematics during collective cell migration 

      Serra-Picamal, Xavier; Conte, Vito; Sunyer, Raimon; Muñoz Romero, José; Trepat, Xavier (2015-01-08)
      Article
      Restricted access - publisher's policy
      Fundamental biological processes including morphogenesis and tissue repair require cells to migrate collectively. In these processes, epithelial or endothelial cells move in a cooperative manner coupled by intercellular ...
    • Robust mechanisms of ventral furrow invagination require the combination of cellular shape changes 

      Conte, Vito; Muñoz Romero, José; Baum, Buzz; Miodownik, M. (2009-05)
      Article
      Open Access
      Ventral furrow formation in Drosophila is the first large-scale morphogenetic movement during the life of the embryo, and is driven by co-ordinated changes in the shape of individual epithelial cells within the cellular ...
    • Stress dependent morphogenesis continuum mechanics and system of trusses 

      Muñoz Romero, José; Conte, Vito; Miodownik, M. (Nova Publishers, 2010-08-30)
      Part of book or chapter of book
      Restricted access - publisher's policy
      The mechanical analysis of soft tissues in biomechanics has undergone an increasing progress during the last decade. Part of this success is due to the development and application of some techniques of continuum mechanics, ...
    • Truss model for stress controlled morphogenesis 

      Muñoz Romero, José; Conte, Vito; Miodownik, M. (2009)
      Conference lecture
      Open Access
      We resort to the usual decomposition of the deformation gradient into an active and a passive component, and deduce the constitutive law and equilibrium equations when the two components are not independent. In the model ...