Now showing items 1-17 of 17

  • Amyloid-like fibrils from a diphenylalanine capped with an aromatic fluorenyl 

    Martí Ballesté, Dídac; Mayans Tayadella, Enric; Gil, Ana M.; Díaz Andrade, Angélica María; Jimenez Sanz, Ana Isabel; Yousef, Ibraheem; Keridou, Ina; Cativiela, Carlos; Puiggalí Bellalta, Jordi; Alemán Llansó, Carlos (2018-11-19)
    Article
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    The self-assembly behavior of a diphenylalanine amphiphile blocked at the C-terminus with a 9-fluorenylmethyl ester and stabilized at the N-terminus with a trifluoroacetate (TFA) anion, TFA·FF-OFm, has been examined. At ...
  • Antimicrobial electrospun fibers of polyester loaded with engineered cyclic gramicidin analogues 

    Maione, Silvana; Valle Mendoza, Luis Javier del; Pérez Madrigal, Mª del Mar; Cativiela, Carlos; Puiggalí Bellalta, Jordi; Alemán Llansó, Carlos (2017)
    Article
    Open Access
    Biodegradable polyester fibers have been loaded with two engineered analogues of gramicidin soviet. In these cyclic peptide derivatives, which were designed in a previous work to stabilize the bioactive conformation while ...
  • Conformational Preferences of 1-Amino-2-phenylcyclohexanecarboxylic Acid, a Phenylalanine Cyclohexane Analogue 

    Alemán Llansó, Carlos; Jimenez, Ana I; Cativiela, Carlos; Nussinov, Ruth; Casanovas, Jordi (2009-10)
    Article
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    The intrinsic conformational preferences of the restricted phenylalanine analogue generated by including the R and β carbon atoms into a cyclohexane ring (1-amino-2-phenylcyclohexanecarboxylic acid, c6Phe) have been ...
  • Conformational preferences of proline analogues with a fused benzene ring 

    Warren, Javier G.; Revilla López, Guillermo; Alemán Llansó, Carlos; Jimenez Sanz, Ana Isabel; Cativiela, Carlos; Torras Costa, Juan (2010-09-16)
    Article
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    The intrinsic conformational preferences of indoline-2-carboxylic acid (Inc) and its R-methylated derivative (RMeInc) have been investigated using quantum mechanical calculations. Specifically, the behavior of ...
  • Diversity and hierarchy in supramolecular assemblies of triphenylalanine: from laminated helical ribbons to toroids 

    Mayans Tayadella, Enric; Casanovas Salas, Jordi; Gil, Ana M.; Jimenez Sanz, Ana Isabel; Cativiela, Carlos; Puiggalí Bellalta, Jordi; Alemán Llansó, Carlos (2017-04-04)
    Article
    Open Access
    Microstructures from small phenylalanine-based peptides have attracted great attention lately because these compounds are considered to be a new class of tunable materials. In spite of the extensive studies on uncapped ...
  • Effect of solvent choice on the self-assembly properties of a diphenylalanine amphiphile stabilized by an ion pair 

    Mayans Tayadella, Enric; Ballano Ballano, María Gema; Sendros, Javier; Font Bardia, Mercè; Campos López, Josefina de Lourdes; Puiggalí Bellalta, Jordi; Cativiela, Carlos; Alemán Llansó, Carlos (2017-07-19)
    Article
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    A diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules ...
  • Effects of ring contraction on the conformational preferences of a-substituted proline analogs 

    Revilla López, Guillermo; Warren, Javier G.; Torras Costa, Juan; Jiménez, Ana I.; Cativiela, Carlos; Alemán Llansó, Carlos (2012-03-01)
    Article
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    The structural consequences derived from the incorporation of either a methyl or a phenyl group at the a carbon of proline were recently investigated by quantum mechanical calculations (J Org Chem 2008, 73, 3418). In ...
  • Electroactive polymer-peptide conjugates for adhesive biointerfaces 

    Maione, Silvana; Gil, Ana M.; Fabregat Jové, Georgina; Valle Mendoza, Luis Javier del; Triguero Enguídanos, Jordi; Laurent, A.; Jacquemin, Denis; Estrany Coda, Francesc; Jimenez Sanz, Ana Isabel; Zanuy Gomara, David; Cativiela, Carlos; Alemán Llansó, Carlos (Royal Society of Chemistry, 2015-01-01)
    Article
    Open Access
    Electroactive polymer-peptide conjugates have been synthesized by combining poly(3,4-ethylenedioxythiophene), a polythiophene derivative with outstanding properties, and an Arg-Gly-Asp (RGD)-based peptide in which Gly has ...
  • Electro-biocompatibility of conjugates designed by chemical similarity 

    Maione, Silvana; Fabregat Jové, Georgina; Valle Mendoza, Luis Javier del; Ballano Ballano, María Gema; Cativiela, Carlos; Alemán Llansó, Carlos (2014-07-01)
    Article
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    The roughness and thickness of films formed by hybrid conjugates prepared by coupling poly(3,4-ethylenedioxythiophene) and synthetic amino acids bearing a 3,4-ethylenedioxythiophene group in the side chain have been ...
  • Electrospray loading and release of hydrophobic gramicidin in polyester microparticles 

    Maione, Silvana; Valle Mendoza, Luis Javier del; Pérez Madrigal, Mª del Mar; Cativiela, Carlos; Puiggalí Bellalta, Jordi; Alemán Llansó, Carlos (2016)
    Article
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    Gramicidin (GA), a very hydrophobic pentadecapeptide with important biological activities (i.e. in addition to its well-known antimicrobial and antibiotic activities, GA has been recently identified as a potent therapeutic ...
  • Engineering strategy to improve peptide analogs: from structure-based computational design to tumor homing 

    Zanuy Gomara, David; Sayago García, Francisco Javier; Revilla López, Guillermo; Ballano Ballano, María Gema; Agemy, Lilach; Kotamraju, Venkata Ramana; Jimenez, Ana I.; Cativiela, Carlos; Nussinov, Ruth; Sawvel, April M.; Ruoslahti, Erkki; Stucky, Galen; Alemán Llansó, Carlos (2013-01)
    Article
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    We present a chemical strategy to engineer analogs of the tumor-homing peptide CREKA (Cys-Arg- Glu-Lys-Ala), which binds to fibrin and fibrin-associated clotted plasma proteins in tumor vessels (Simberg et al. in Proc ...
  • Hierarchical self-assembly of di-, tri- and tetraphenylalanine peptides capped with two fluorenyl functionalities: from polymorphs to dendrites 

    Mayans Tayadella, Enric; Ballano Ballano, María Gema; Casanovas Muñoz, Jordi; Valle Mendoza, Luis Javier del; Pérez Madrigal, Mª del Mar; Estrany Coda, Francesc; Jimenez Sanz, Ana Isabel; Puiggalí Bellalta, Jordi; Cativiela, Carlos; Alemán Llansó, Carlos (2016)
    Article
    Open Access
    Homopeptides with 2, 3 and 4 phenylalanine (Phe) residues and capped with fluorenylmethoxycarbonyl and fluorenylmethyl esters at the N-terminus and C-terminus, respectively, have been synthesized to examine their self-assembly ...
  • Hybrid polypeptide/polylactide copolymers with short phenylalanine blocks 

    Mayans Tayadella, Enric; Murase Fernández, Sara Keiko; Pérez Madrigal, Maria del Mar; Cativiela, Carlos; Alemán Llansó, Carlos; Puiggalí Bellalta, Jordi (2018-07-29)
    Article
    Open Access
    Hybrid copolymers constituted by short l-phenylalanine (Phe) blocks (i.e., Phen with n ranging from 2 to 25) and l-lactide blocks of different length are synthesized and characterized. The diblock structure is obtained by ...
  • NCAD, a database integrating the intrinsic conformational preferences of non-coded amino acids 

    Alemán Llansó, Carlos; Grodzinski, Piotr; Nussinov, Ruth; Revilla López, Guillermo; Torras Costa, Juan; Curcó, David; Casanovas, Jordi; Calaza, Maria Isabel; Zanuy Gomara, David; Jimenez Sanz, Ana Isabel; Cativiela, Carlos (2010-05-10)
    Article
    Open Access
    Peptides and proteins find an ever-increasing number of applications in the biomedical and materials engineering fields. The use of non-proteinogenic amino acids endowed with diverse physicochemical and structural ...
  • Peptide delta-turn: Literature survey and recent progress 

    Toniolo, Claudio; Crisma, Marco; Moretto, Alessandro; peggion, Cristina; Formaggio, Fernando; Alemán Llansó, Carlos; Cativiela, Carlos; Ramakrishnan, Chandrasekharan; Balaram, Padmanabhan (2015-09-28)
    Article
    Open Access
    Among the various types of a-peptide folding motifs, delta-turn, which requires a central cis-amide disposition, has been one of the least extensively investigated. In particular, this main-chain reversal topology has been ...
  • Surface mediated hierarchical assemblies of highly hydrophobic phenylalanine-based peptides 

    Mayans Tayadella, Enric; Fabregat Jové, Georgina; Juarez Dominguez, Ruben; Cativiela, Carlos; Puiggalí Bellalta, Jordi; Alemán Llansó, Carlos (2017-01-01)
    Article
    Open Access
    We report the noticeable control exerted by the surface in the self-assembly of a highly hydrophobic triphenylalanine peptide with fluorenyl functionalities blocking the two ends. The remarkable differences observed among ...
  • Synergistic computational-experimental approach to improve ionene polymer-based functional hydrogels 

    Bachl, Jürgen; Zanuy Gomara, David; López Pérez, Daniel Ernesto; Revilla López, Guillermo; Cativiela, Carlos; Alemán Llansó, Carlos; Diaz Diaz, David (2014-08-20)
    Article
    Restricted access - publisher's policy
    The manifold applications of ionene-based materials such as hydrogels in daily life, biomedical sciences, and industrial processes are a consequence of their unique physical and chemical properties, which are governed by ...