Browsing by Author "Brito, Catarina"
Now showing items 1-4 of 4
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3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment
Rebelo, Sofia P.; Martins, Tatiana R.; Estrada, Marta F.; Loza Álvarez, Pablo; Harrer, Nathalie; Alves, Paula M.; Cabeçadas, Jose; Gualda Manzano, Emilio José; Sommergruber, Wolfgang; Brito, Catarina (2018-05)
Article
Open AccessThe tumour microenvironment (TME) shapes disease progression and influences therapeutic response.Most aggressive solid tumours have high levels of myeloid cell infiltration, namely tumour associatedmacrophages (TAM). ... -
Imaging of human differentiated 3D neural aggregates using light sheet fluorescence microscopy
Gualda Manzano, Emilio José; Brito, Catarina; Simão, Daniel; Pinto, Catarina; Alves, Paula M. (2014-08-06)
Article
Open AccessThe development of three dimensional (3D) cell cultures represents a big step for the better understanding of cell behavior and disease in a more natural like environment, providing not only single but multiple cell type ... -
Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression
Gualda Manzano, Emilio José; Estrada, Marta F.; Alves, Paula M.; Brito, Catarina (2016-02)
Article
Open Access3D cell tumour models are generated mainly in non-scalable culture systems, using bioactive scaffolds. Many of these models fail to reflect the complex tumour microenvironment and do not allow long-term monitoring of ... -
SPIM-fluid: open source light-sheet based platform for high-throughput imaging
Gualda Manzano, Emilio José; Pereira, Hugo; Vale, Tiago; Falcao Estrada, Marta; Brito, Catarina (2015-11-01)
Article
Open AccessLight sheet fluorescence microscopy has recently emerged as the technique of choice for obtaining high quality 3D images of whole organisms/embryos with low photodamage and fast acquisition rates. Here we present an ...