Now showing items 1-4 of 4

    • Covalent immobilization of hLf1-11 peptide on a titanium surface reduces bacterial adhesion and biofilm formation 

      Godoy Gallardo, Maria; Mas Moruno, Carlos; Fernandez Calderon, Maria C.; Perez Giraldo, Ciro; Manero Planella, José María; Albericio, Fernando; Gil Mur, Francisco Javier; Rodríguez Rius, Daniel (2014-08-01)
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      Bacterial infection represents a major cause of implant failure in dentistry. A common approach to overcoming this issue and treating pen-implant infection consists in the use of antibiotics. However, the rise of ...
    • Design of a minimized cyclic tetrapeptide that neutralizes bacterial endotoxins 

      Mora, Puig; Mas Moruno, Carlos; Tamborero, Silvia; Cruz, Luis Javier; Pérez-Payá, Enrique; Albericio, Fernando (2006)
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      Septic shock is a leading cause of mortality in intensive care patients, and no specific drugs are as yet available for its treatment. Therefore, new leads ar e required in order to increase the numbe r of active ...
    • Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell 

      Cascales, L.; Mas Moruno, Carlos; Tamborero, Silvia; Aceña, J.L.; Sanz, J.F.; Fustero, S.; Cruz, Luis Javier; Albericio, Fernando; Mora, P.; Pérez-Payá, Enrique (2008)
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      The screening of a commercially available library of compounds has proved a successful strategy for the identification of a lead compound in a drug discovery programme. Here, we analysed 880 off-patent drugs, which initially ...
    • Trivalent PEGylated platform for the conjugation of bioactive compounds 

      Torres, A.; Mas Moruno, Carlos; Pérez-Payá, Enrique; Albericio, Fernando; Royo, M. (2011)
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      PEGylated multivalent structures are a new class of platform for biological applications due to their biocompatibility properties. Here, we present the synthesis of a trivalent structure 1 based on poly(ethylene glycol) ...