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Ara es mostren els items 63428-63447 de 245565

    • Discovering social structures of local influence by using tweetStimuli 

      Tejeda Gómez, José Arturo; Sànchez-Marrè, Miquel; Pujol Serra, Josep M. (2013-12-05)
      Article
      Accés restringit per política de l'editorial
      Information diffusion in large-scale networks has been studied to identify the users influence. The influence has been targeted as a key feature either to reach large populations or influencing public opinion. Through the ...

    • Discovering the Ethereum2 P2P network 

      Cortes Goicoechea, Mikel; Bautista Gomez, Leonardo (Institute of Electrical and Electronics Engineers (IEEE), 2021)
      Text en actes de congrés
      Accés obert
      Achieving the equilibrium between scalability, sustainability, and security while keeping decentralization has prevailed as the target solution for decentralized blockchain applications over the last years. Several approaches ...

    • Discovering the Ethereum2 P2P network 

      Cortes Goicoechea, Mikel; Bautista Gomez, Leonardo (Institute of Electrical and Electronics Engineers (IEEE), 2021)
      Comunicació de congrés
      Accés obert
      Achieving the equilibrium between scalability, sustainability, and security while keeping decentralization has prevailed as the target solution for decentralized blockchain applications over the last years. Several approaches ...

    • Discovering the Ethereum2 P2P network 

      Cortes Goicoechea, Mikel; Bautista Gomez, Leonardo (Barcelona Supercomputing Center, 2022-05)
      Text en actes de congrés
      Accés obert
      Achieving the equilibrium between scalability, sus­tainability, and security while keeping decentralization has pre­ vailed as the target solution for decentralized blockchain ap­ plications over the last few years. ...

    • Discovering the network topology: an efficient approach for SDN 

      Ochoa Aday, Leonardo; Cervelló Pastor, Cristina; Fernández Fernández, Adriana (2016-11)
      Article
      Accés obert
      Network topology is a physical description of the overall resources in the network. Collecting this information using efficient mechanisms becomes a critical task for important network functions such as routing, network ...

    • Discovering the power of agent-based modelling to deal with complex systems in diverse contexts 

      Ginovart Gisbert, Marta; Portell Canal, Xavier; Blanco Abellán, Mónica (2011)
      Text en actes de congrés
      Accés restringit per política de l'editorial
      Modelling is a necessary tool to represent, analyse and discuss aspects or ideas related to complex systems. With this in mind, teaching science based on the elaboration of models is widely accepted in the academic ...

    • Discovering the power of individual-based modelling in teaching and learning: the study of a predator–prey system 

      Ginovart Gisbert, Marta (2013)
      Article
      Accés restringit per política de l'editorial
      The general aim is to promote the use of individual- based models (biological agent-based models) in teaching and learning contexts in life sciences and to make their progressive incorporation into academic curricula ...

    • Discovering unbounded episodes in sequential data 

      Casas Garriga, Gemma (2003-04)
      Report de recerca
      Accés obert
      One basic goal in the analysis of time-series data is to find frequent interesting episodes, i.e, collections of events occurring frequently together in the input sequence. Most widely-known work decide the interestingness ...

    • Discovery and learning of navigation goals from pixels in Minecraft 

      Nieto Salas, Juan José (Universitat Politècnica de Catalunya, 2021-05-27)
      Projecte Final de Màster Oficial
      Accés obert
      Pre-training Reinforcement Learning (RL) agents in a task-agnostic manner has shown promising results. However, previous works still struggle to learn and discover meaningful skills in high-dimensional state-spaces. We ...

    • Discovery and validation of clinically relevant long non-coding RNAs in colorectal cancer 

      Snyder, Madison; Iraola Guzmán, Susana; Saus, Ester; Gabaldón, Toni (MDPI, 2022-08)
      Article
      Accés obert
      Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with nearly two million newly diagnosed cases each year. The survival of patients with CRC greatly depends on the cancer stage at the time of diagnosis, ...

    • Discovery of a bradykinin b2 partial agonist profile of raloxifene in a drug repurposing campaign 

      Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-12-29)
      Article
      Accés obert
      Covid-19 urges a deeper understanding of the underlying molecular mechanisms involved in illness progression to provide a prompt therapeutical response with an adequate use of available drugs, including drug repurposing. ...

    • Discovery of Cl-34g,Cl-m(p,gamma)Ar-35 resonances activated at classical nova temperatures 

      Fry, C.; Wrede, Christopher; Bishop, Shawn M.; Brown, B. A.; Chen, Alan A.; Faestermann, Thomas; Hertenberger, R.; Parikh, Anuj Ramesh; Perez Loureiro, D; Wirth, Hans Friedrich; Garcia, A.; Ortez, Ronaldo (2015-01-13)
      Article
      Accés obert
      Background: The thermonuclear Cl-34g,Cl-m(p,gamma)Ar-35 reaction rates are unknown due to a lack of experimental nuclear physics data. Uncertainties in these rates translate to uncertainties in S-34 production in models ...

    • Discovery of diverse natural products as inhibitors of SARS-CoV-2 Mpro protease through virtual screening 

      Rubio Martínez, Jaime; Jiménez Alesanco, Ana; Ceballos Laita, Laura; Ortega Alarcón, David; Vega, Sonia; Calvo, Cristina; Benítez García, Cristina; Abian, Olga; Velázquez Campoy, Adrián; Thomson, Timothy M.; Granadino Roldán, José Manuel; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2021-11-22)
      Article
      Accés obert
      SARS-CoV-2 is a type of coronavirus responsible for the international outbreak of respiratory illness termed COVID-19 that forced the World Health Organization to declare a pandemic infectious disease situation of international ...

    • Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter 

      Pittis, Alexandros A.; Goh, Valerie; Cebrian Serrano, Alberto; Wettmarshausen, Jennifer; Perocchi, Fabiana; Gabaldón, Toni (Nature Research, 2020)
      Article
      Accés obert
      Calcium (Ca2+) influx into mitochondria occurs through a Ca2+-selective uniporter channel, which regulates essential cellular processes in eukaryotic organisms. Previous evolutionary analyses of its pore-forming subunits ...

    • Discovery of hit compounds targeting the P4 allosteric site of K-RAS, identified through ensemble-based virtual screening 

      Gómez Gutiérrez, Patricia; Rubio Martínez, Jaime; Pérez González, Juan Jesús (American Chemical Society, 2023-10-12)
      Article
      Accés obert
      Mutants of Ras are oncogenic drivers of a large number of human tumors. Despite being recognized as an attractive target for the treatment of cancer, the high affinity for its substrate tagged the protein as undruggable ...

    • Discovery of new selective antagonists of G-protein coupled receptors of therapeutic interest 

      Lupala, Cecylia Severin (Universitat Politècnica de Catalunya, 2016-01-28)
      Tesi
      Accés obert
      GPCR are integral membrane receptor proteins that are characterized by heptahelical transmembrane domains connected by intracellular and extracellular loops. GPCRs are an attractive class of proteins for drug discovery, ...

    • Discovery of novel 2,3,5-trisubstituted pyridine analogs as potent inhibitors of IL-1ß via modulation of the p38 MAPK signaling pathway 

      Carrasco, Esther; Gómez Gutierrez, Patricia; Campos Muelas, Pedro Manuel; Vega, Miguel; Messeguer, Angel; Pérez González, Juan Jesús (2021-11-05)
      Article
      Accés obert
      Interleukin-1ß is a central mediator of innate immune responses and inflammation. It plays a key role in a wide variety of pathologies, ranging from autoinflammatory diseases to metabolic syndrome and malignant tumors. It ...

    • Discovery of personal processes from labeled sensor data: An application of process mining to personalized health care 

      Sztyler, Timo; Völker, Johanna; Carmona Vargas, Josep; Meier, Oliver; Stuckenschmidt, Heiner (CEUR-WS.org, 2015)
      Text en actes de congrés
      Accés obert
      Currently, there is a trend to promote personalized health care in order to prevent diseases or to have a healthier life. Using current devices such as smart-phones and smart-watches, an individual can easily record detailed ...

    • Discovery of soft and hard X-ray time lags in low-mass AGNs 

      Mallick, L.; Wilkins, Daniel Richard; Alston, William; Markowitz, Alex; Marco, Barbara de; Parker, Michael L.; Lohfink, Anne M.; Stalin, Chelliah Subramonian (Oxford University Press, 2021-03-05)
      Article
      Accés obert
      The scaling relations between the black hole (BH) mass and soft lag properties for both active galactic nuclei (AGNs) and BH X-ray binaries (BHXRBs) suggest the same underlying physical mechanism at work in accreting BH ...

    • Discovery of spatio-temporal patterns from location based social networks 

      Béjar Alonso, Javier; Álvarez Napagao, Sergio; Garcia Gasulla, Dario; Gómez Sebastià, Ignasi; Oliva Felipe, Luis Javier; Tejeda Gómez, José Arturo; Vázquez Salceda, Javier (IOS Press, 2014)
      Text en actes de congrés
      Accés restringit per política de l'editorial
      Location Based Social Networks (LBSN) have become an interesting source for mining user behavior. These networks (e.g. Twitter, Instagram or Foursquare) collect spatio-temporal data from users in a way that they can be ...