Browsing by Subject "G proteins"
Now showing items 1-9 of 9
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A probabilistic approach to the visual exploration of G protein-coupled receptor sequences
(2011)
Conference report
Open AccessThe study of G protein-coupled receptors (GPCRs) is of great interest in pharmaceutical research, but only a few of their 3D structures are known at present. On the contrary, their amino acid sequences are known and ... -
Flavonoid allosteric modulation of mutated visual rhodopsin associated with retinitis pigmentosa
(Macmillan Publishers, 2017-12-01)
Article
Open AccessDietary flavonoids exhibit many biologically-relevant functions and can potentially have beneficial effects in the treatment of pathological conditions. In spite of its well known antioxidant properties, scarce structural ... -
GPCR molecular dynamics forecasting using recurrent neural networks
(Springer Nature, 2023)
Article
Open AccessG protein-coupled receptors (GPCRs) are a large superfamily of cell membrane proteins that play an important physiological role as transmitters of extracellular signals. Signal transmission through the cell membrane depends ... -
Long short-term memory to predict 3D amino acids positions in GPCR molecular dynamics
(IOS Press, 2022)
Conference report
Open AccessG-Protein Coupled Receptors (GPCRs) are a big family of eukaryotic cell transmembrane proteins, responsible for numerous biological processes. From a practical viewpoint around 34% of the drugs approved by the US Food and ... -
Molecular dynamics forecasting of transmembrane regions in GPRCs by recurrent neural networks
(Institute of Electrical and Electronics Engineers (IEEE), 2022)
Conference report
Open AccessG protein-coupled receptors are a large super-family of cell membrane proteins that play an important physiological role as transmitters of extra-cellular signals. Signal transmission through the cell membrane depends on ... -
Molecular features characterizing non-peptide selectivity to the human B1 and B2 bradykinin receptors
(2019-01-01)
Article
Restricted access - publisher's policyBradykinin is produced in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases. Actions of this peptide are mediated through two different G-protein coupled receptors, named B1 and B2 ... -
Structural and functional alterations associated with deutan N94K and R330Q mutations of green cone opsin
(2017-07-01)
Article
Restricted access - publisher's policyDeuteranopia is an X-linked congenital dichromatic condition in which single point mutations in green cone opsin lead to defective non-functional cone photoreceptor cells. Green cone opsin belongs to the G protein-coupled ... -
Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling
(2017-08-13)
Article
Open AccessDespite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design. Despite the number of crystallographic ... -
Using random forests for assistance in the curation of G-protein coupled receptor databases
(2017-08-18)
Article
Open AccessBackground: Biology is experiencing a gradual but fast transformation from a laboratory-centred science towards a data-centred one. As such, it requires robust data engineering and the use of quantitative data analysis ...
