Exploració per autor "Pérez González, Juan Jesús"
Ara es mostren els items 41-57 de 57
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New insights into the stereochemical requirements of the bombesin BB1 receptor antagonists binding
Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-08-17)
Article
Accés obertMembers of the family of bombesinlike peptides exert a wide range of biological activities both at the central nervous system and in peripheral tissues through at least three G-Protein Coupled Receptors: BB1, BB2 and BB3. ... -
New insights into the stereochemical requirements of the bradykinin B1 receptor antagonist binding
Pérez González, Juan Jesús; Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia (2016-07-21)
Article
Accés obertBradykinin (BK) is a nonapeptide involved in several pathophysiological conditions including among others, septic and haemorrhagic shock, anaphylaxis, arthritis, rhinitis, asthma, inflammatory bowel disease. Accordingly, ... -
New insights into the stereochemical requirements of the bradykinin B1 receptor antagonist binding.
Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia; Pérez González, Juan Jesús (2016-07-26)
Article
Accés obertBradykinin (BK) is a nonapeptide involved in several pathophysiological conditions including among others, septic and haemorrhagic shock, anaphylaxis, arthritis, rhinitis, asthma, inflammatory bowel disease. Accordingly, ... -
New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding
Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia; Pérez González, Juan Jesús (2016-01-20)
Article
Accés obertBradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases, provoking vasodilatation and increased vascular permeability among other ... -
On-line quality assurance of study programmes: EQUASP approach
Suqarzoni, Alfredo; Pérez González, Juan Jesús; Mager, Vladimir (2016-04-05)
Article
Accés obertThe description of the EQUASP model for quality assurance of study programmes, developed in framework of a TEMPUS project, is introduced. The introduction section contains brief information on the concept of quality and ... -
Randomized tree construction algorithm to explore energy landscapes
Jaillet, Leonard Georges; Corcho Sánchez, Francisco José; Pérez González, Juan Jesús; Cortés, Juan (2011-12)
Article
Accés obertWe report in the present work a new method for exploring conformational energy landscapes. The method, called T-RRT, combines ideas from statistical physics and robot path planning algorithms. A search tree is constructed ... -
Rational design of new class of BH3-mimetics as inhibitors of the Bcl-X(L) protein
Pinto Manresa, Marta; Orzaez, Maria del Mar; Delgado-Soler, L.; Pérez González, Juan Jesús; Rubio Martinez, Jaime (2011-06)
Article
Accés obertThe Bcl-2 family of proteins plays an important role in the intrinsic pathway of cell apoptosis. Overexpression of prosurvival members of this family of proteins is often associated with the development of many types of ... -
Social responsibility as a transversal competence of graduates
Pérez González, Juan Jesús (2016)
Text en actes de congrés
Accés obertPaper purpose: The aim of the present communication is to propose a procedure to assess the level of competence achieved by graduates. Design/methodology/theoretical approach: We propose to use a quality assurance ... -
Structural characterization of a zinc high-affinity binding site in rhodopsin
Darwin, Toledo; Cordomí Montoya, Arnau; Proietti, Maria Grazia; Maurizio, Benfatto; Valle Mendoza, Luis Javier del; Pérez González, Juan Jesús; Garriga Solé, Pere; Sepulcre Sánchez, Francesc (2009-02)
Article
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Structural study of a new HIV-1 entry inhibitor and interaction with the HIV-1 fusion peptide in dodecylphosphocholine micelles
Pérez González, Juan Jesús; Pérez, Yolanda; Gómara, Maria José; Yuste, Eloísa; Gómez Gutierrez, Patricia; Haro, Isabel (2017-07-03)
Article
Accés obertPrevious studies support the hypothesis that the envelope GB virus C (GBV-C) E1 protein interferes the HIV-1 entry and that a peptide, derived from the region 139-156 of this protein, has been defined as a novel HIV-1 entry ... -
Structural study of a retro-enantiomer peptide with possible application in the pre-exposure prophylaxis of HIV infection
Gómara Elena, María José; Pérez, Yolanda; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (Nature, 2020-09-02)
Article
Accés obertBased on the structure of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed to provide novel prevention interventions against HIV transmission. The three peptides show greater ... -
Structure-activity studies of novel Di-substituted [1,2,5]oxadiazolo [3,4-b]pyrazine analogs targeting the A-loop regulatory site of p38 MAP kinase
Carrasco, Esther; Gómez Gutiérrez, Patricia; Campos Muelas, Pedro Manuel; Vega, Miguel; Pérez González, Juan Jesús (Bentham Science Publishers, 2022-03-01)
Article
Accés obertIntroduction: In the quest for novel allosteric inhibitors of the p38 MAP kinase, we recently described the A-loop regulatory site, identified by means of molecular modeling studies together with the disclosure of a small ... -
Synthesis, Langmuir and Langmuir-Blodgett films of a calix[7]arene ethyl ester
Torrent Burgués, Juan; Vocanson, Francis; Pérez González, Juan Jesús; Errachid, Abdelhamid (Elsevier, 2012)
Article
Accés obert -
Synthesis, Langmuir and Langmuir-Blodgett films of a calix[7]arene ethyl ester. AFM characterization, subphase influence and molecular modelling
Torrent Burgués, Juan; Vocanson, Francis; Pérez González, Juan Jesús; Errachid, Abdhellamid (Elsevier, 2012-05-05)
Article
Accés restringit per política de l'editorialCalixarenes are promising compounds to be used as ionophores and for molecular recognition. Their ability to form Langmuir and Langmuir–Blodgett (LB) films is of great interest in order to obtain small sensor devices which ... -
Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model
Gago López, Nuria; Lagunas Arnal, Carmen; Pérez González, Juan Jesús; Wagner, Erwin F. (2021-11-30)
Article
Accés obertPsoriasis is a chronic inflammatory skin disease without cure. Systemic and biological therapies are the most effective treatments for patients with severe psoriasis. However, these drugs can cause serious side effects ... -
Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling
Lupala, Cecylia Severin; Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2017-08-13)
Article
Accés obertDespite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design. Despite the number of crystallographic ... -
Zinc is involved in depression by modulating G-protein-coupled receptor heterodimerization
Tena Campos, Mercè; Ramon Portés, Eva; Lupala, Cecylia Severin; Pérez González, Juan Jesús; Koch, Karl-Wilhelm; Garriga Solé, Pere (2016-04)
Article
Accés obert5-Hydroxytryptamine 1A receptor and galanin receptor 1 belong to the G protein-coupled receptors superfamily, and they have been described to heterodimerize triggering an anomalous physiological state that would underlie ...