Ara es mostren els items 21-40 de 48

    • Isohexide and sorbitol-derived, enzymatically synthesized renewable polyesters with enhanced Tg 

      Gustini, Liliane; Lavilla, Cristina; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián; Koning, Cor (2016-10-10)
      Article
      Accés obert
      Sugar-based polyesters derived from sorbitol and isohexides were obtained via solvent-free enzymatic catalysis. Pendant hydroxyl groups, coming from the sorbitol units, were present along the polyester backbone, whereas ...
    • Known evolutionary paths are accessible to engineered ß-Lactamases having altered protein motions at the timescale of catalytic turnover 

      Alejaldre, Lorea; Lemay-St-Denis, Claudèle; Perez Lopez, Carles; Sancho Jodar, Ferran; Guallar, Victor; Pelletier, Joelle N. (Frontiers, 2020)
      Article
      Accés obert
      The evolution of new protein functions is dependent upon inherent biophysical features of proteins. Whereas, it has been shown that changes in protein dynamics can occur in the course of directed molecular evolution ...
    • Laccase from Pycnoporus cinnabarinus and phenolic compounds: can the efficiency of an enzyme mediator for delignifying kenaf pulp be predicted? 

      Andreu Terrén, Glòria; Vidal Lluciá, Teresa (2012-03)
      Article
      Accés restringit per política de l'editorial
      In this work, kenaf pulp was delignified by using laccase in combination with various redox mediators and the efficiency of the different laccase–mediator systems assessed in terms of the changes in pulp properties after ...
    • Mapping enzyme-substrate interactions: its potential to study the mechanism of enzymes 

      Roda, Sergi; Santiago, Gerard; Guallar, Victor (Academic Press Inc., 2020-09)
      Capítol de llibre
      Accés obert
      With the increase of the need to use more sustainable processes for the industry in our society, the modeling of enzymes has become crucial to fully comprehend their mechanism of action and use this knowledge to enhance ...
    • Mapping the Long-Range Electron Transfer Route in Ligninolytic Peroxidases 

      Acebes, Sandra; Ruiz-Dueñas, Francisco J.; Toubes, Mario; Sáez-Jiménez, Veronica; Pérez-Boada, Marta; Lucas, M. Fatima; Martínez, Angel T.; Guallar, Victor (ACS Publications, 2017-04-04)
      Article
      Accés obert
      Combining a computational analysis with site-directed mutagenesis, we have studied the long-range electron transfer pathway in versatile and lignin peroxidases, two enzymes of biotechnological interest that play a key role ...
    • Mechanistic insights into the reaction of chlorination of tryptophan catalyzed by tryptophan 7-halogenase 

      Karabencheva Christova, Tatyana G.; Torras Costa, Juan; Mulholland, Adrian J.; Lodola, Alessio; Christov, Christo Z. (Macmillan Publishers, 2017-12-12)
      Article
      Accés obert
      Tryptophan 7-halogenase catalyzes chlorination of free tryptophan to 7-chlorotryptophan, which is the first step in the antibiotic pyrrolnitrin biosynthesis. Many biologically and pharmaceutically active natural products ...
    • Metagenomic mining for esterases in the microbial community of Los Rueldos acid mine drainage formation 

      Vidal, Paula; Martínez Martínez, Mónica; Fernandez Lopez, Laura; Roda, Sergi; Méndez García, Celia; Golyshina, Olga V.; Guallar, Victor; Pelaez, Ana Isabel; Ferrer, Manuel (Frontiers Media, 2022-05)
      Article
      Accés obert
      Acid mine drainage (AMD) systems are extremely acidic and are metal-rich formations inhabited by relatively low-complexity communities of acidophiles whose enzymes remain mostly uncharacterized. Indeed, enzymes from only ...
    • Modelización de la acción de una proteasa en las características físicas de un tejido de lana 

      Cegarra Sánchez, José; Pepió Viñals, Montserrat; Naik Kardile, Arun; Riva Juan, Ascensión (Instituto de Investigación Textil y Cooperación Industrial, 2004-01)
      Article
      Accés obert
      Se estudia la acción de proteasas en una serie de propiedades físicas de tejidos de calada, considerando la aplicación de este tipo de enzimas en el acabado textil. Se estudia la influencia de la concentración de enzima, ...
    • Molecular Modeling in Enzyme Design, Toward In Silico Guided Directed Evolution 

      Monza, Emanuele; Acebes, Sandra; Lucas, Fátima; Guallar, Victor (Springer, 2017-02-15)
      Capítol de llibre
      Accés obert
      Directed evolution (DE) creates diversity in subsequent rounds of mutagenesis in the quest of increased protein stability, substrate binding, and catalysis. Although this technique does not require any structural/mechanistic ...
    • Multiple implications of an active site phenylalanine in the catalysis of aryl-alcohol oxidase 

      Carro, Juan; Amengual-Rigo, Pep; Sancho, Ferran; Medina, Milagros; Guallar, Victor; Ferreira, Patricia; Martinez, Angel T. (Nature Publishing Group, 2018-05-25)
      Article
      Accés obert
      Aryl-alcohol oxidase (AAO) has demonstrated to be an enzyme with a bright future ahead due to its biotechnological potential in deracemisation of chiral compounds, production of bioplastic precursors and other reactions ...
    • Nano-engineering stable contact-based antimicrobials: Chemistry at the interface between nano-gold and bacteria 

      Vukomanovic, Marija; Cendra Gascón, María del Mar; Baelo, Aida; Torrents Serra, Eduard (Elsevier, 2021-12)
      Article
      Accés obert
      Contact-based antimicrobials, as antibiotic-free technologies that use non-specific interactions with bacterial cells to exert antimicrobial activity, are a prospective solution in fighting the global issue of bacterial ...
    • Obtenció de nanocel·lulosa utilitzant enzims 

      Barrabino Clemente, Loreto (Universitat Politècnica de Catalunya, 2016-04-26)
      Treball Final de Grau
      Accés obert
      Els nanocristalls de cel·lulosa (NCC) tenen unes propietats físico-mecàniques i de biocompatibilitat que es poden aplicar als camps de biomedicina, electrònica i farmacèutica. Els NCC s’obtenen a partir d’una hidròlisis ...
    • Oxidoreductases on their way to industrial biotransformations 

      Martinez, Angel T.; Ruiz-Dueñas, Francisco; Camarero, Susana; Serrano, Ana; Linde, Dolores; Lund, Henrik; Vind, Jesper; Tovborg, Morten; Herold-Majumdar, Owik M.; Hofrichter, Martin; Liers, Christiane; Ullrich, René; Scheibner, Katrin; Sannia, Giovanni; Piscitelli, Alessandra; Pezzella, Cinzia; Sener, Mehmet E.; Kiliç, Sibel; van Berkel, Willhem J.H.; Guallar, Victor; Lucas, Fátima; Zuhse, Ralf; Ludwig, Roland; Hollmann, Frank; Fernández-Fueyo, Elena; Record, Eric; Faulds, Craig B.; Tortajada, Marta; Winckelmann, Ib; Rasmussen, Jo-Anne; Gelo-Pujic, Mirjana; Gutiérrez, Ana; del Río, José C.; Rencoret, Jorge; Alcalde, Miguel (Elsevier, 2017-11)
      Article
      Accés obert
      Fungi produce heme-containing peroxidases and peroxygenases, flavin-containing oxidases and dehydrogenases, and different copper-containing oxidoreductases involved in the biodegradation of lignin and other recalcitrant ...
    • PluriZymes: new enzymes for new times 

      Domingo-Cabasés, Marc; Rodà, Sergi; Santiago, Gerard; Guallar, Victor (Barcelona Supercomputing Center, 2019-05-07)
      Text en actes de congrés
      Accés obert
    • Probing the Surface of a Laccase for Clues towards the Design of Chemo-Enzymatic Catalysts 

      Robert, Viviane; Monza, Emanuele; Tarrago, Lionel; Sancho, Ferran; de Falco, Ana; Schneider, Ludovic; Ngoutane, Eloïne N.; Mekmouche, Yasmina; Pailley, Pierre R.; Simaan, A. Jalila; Guallar, Victor; Tron, Thierry (Wiley, 2017-04)
      Article
      Accés obert
      Systems featuring a multi-copper oxidase associated with transition-metal complexes can be used to perform oxidation reactions in mild conditions. Here, a strategy is presented for achieving a controlled orientation of a ...
    • Protein modelling for enzyme engineering 

      Santiago, Gerard; Guallar, Victor (Barcelona Supercomputing Center, 2017-05-04)
      Text en actes de congrés
      Accés obert
    • Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity 

      Koncitikova, Radka; Zuily, Lisa; Lemarié, Emeline; Ribeaucourt, David; Saker, Safwan; Haon, Mireille; Brumer, Harry; Guallar, Victor; Berrin, Jean-Guy; Lafond, Mickael (Wiley, 2023)
      Article
      Accés obert
      Fungal copper radical oxidases (CROs) from the Auxiliary Activity family 5 (AA5) constitute a group of metalloenzymes that oxidize a wide panel of natural compounds, such as galactose-containing saccharides or primary ...
    • Rational Engineering of Multiple Active Sites in an Ester Hydrolase 

      Santiago, Gerard; Martínez-Martínez, Mónica; Alonso, Sandra; Bargiela, Rafael; Coscolín, Cristina; Golyshing, Peter N.; Guallar, Victor; Ferrer, Manuel (American Chemical Society, 2018-03-30)
      Article
      Accés obert
      Effects of altering the properties of an active site in an enzymatic homogeneous catalyst have been extensively reported. However, the possibility of increasing the number of such sites, as commonly done in heterogeneous ...
    • Rational Enzyme Engineering Through Biophysical and Biochemical Modeling 

      Acebes, Sandra; Fernández-Fueyo, Elena; Monza, Emanuele; Lucas, Fatima; Almendral, David; Ruiz-Dueñas, Fracisco J.; Lund, Henrik; Martínez, Ángel T.; Guallar, Víctor (ACS Publications, 2016-02-03)
      Article
      Accés obert
      Due to its importance in the pharmaceutical industry, ligand dynamic simulations have experienced a great expansion. Using all-atom models and cutting edge hardware, one can perform non-biased ligand migration, active site ...
    • Repurposing designed mutants: a valuable strategy for computer-aided laccase engineering – the case of POXA1b 

      Giacobelli, Valerio G.; Monza, Emanuele; Lucas, M. Fatima; Pezzella, Cinzia; Piscitelli, Alessandra; Guallar, Victor; Sannia, Giovanni (Royal Society of Chemistry, 2017-01-04)
      Article
      Accés obert
      The broad specificity of laccases, a direct consequence of their shallow binding site, makes this class of enzymes a suitable template to build specificity toward putative substrates. In this work, a computational methodology ...