Exploració per tema "Cancer"
Ara es mostren els items 21-40 de 46
-
Fine tuning a logical model of cancer cells to predict drug synergies: combining manual curation and automated parameterization
(Frontiers Media, 2023)
Article
Accés obertTreatment with combinations of drugs carries great promise for personalized therapy for a variety of diseases. We have previously shown that synergistic combinations of cancer signaling inhibitors can be identified based ... -
Graphlet eigencentralities capture novel central roles of genes in pathways
(Public Library of Science, 2022-01)
Article
Accés obertMotivation Graphlet adjacency extends regular node adjacency in a network by considering a pair of nodes being adjacent if they participate in a given graphlet (small, connected, induced subgraph). Graphlet adjacencies ... -
Human metastatic cholangiocarcinoma patient-derived xenografts and tumoroids for preclinical drug evaluation
(American Association for Cancer Research, 2023)
Article
Accés obertCholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations ... -
Hydroxyapatite biobased materials for treatment and diagnosis of cancer
(2022-10-01)
Article
Accés obertGreat advances in cancer treatment have been undertaken in the last years as a consequence of the development of new antitumoral drugs able to target cancer cells with decreasing side effects and a better understanding of ... -
Identifying cellular cancer mechanisms through pathway-driven data integration
(Oxford University Press, 2022)
Article
Accés obertMotivation Cancer is a genetic disease in which accumulated mutations of driver genes induce a functional reorganization of the cell by reprogramming cellular pathways. Current approaches identify cancer pathways as those ... -
Identifying cellular cancer mechanisms through pathway-driven data integration
(Oxford University Press, 2022-08-02)
Article
Accés obertAbstract Motivation Cancer is a genetic disease in which accumulated mutations of driver genes induce a functional reorganization of the cell by reprogramming cellular pathways. Current approaches identify cancer pathways ... -
Incorporation of functionalized calcium phosphate nanoparticles in living cells
(Springer Nature, 2021-11-05)
Article
Accés obertIntracellular calcium (Ca2+) is a key signaling element that is involved in a great variety of fundamental biological processes. Thus, Ca2+ deregulation would be involved in the cancer cell progression and damage of ... -
Inhibition of Human Enhancer of Zeste Homolog 2 (EZH2) with Tambjamine Analogs
(American Chemical Society, 2017-08-01)
Article
Accés obertCombining computational modeling, de novo compound synthesis, and in vitro and cellular assays, we have performed an inhibition study against the enhancer of zeste homolog 2 (EZH2) histone-lysine N-methyltransferase. This ... -
Large-scale machine learning in cancer and brain research: new applications that will drive future supercomputing systems
(Barcelona Supercomputing Center, 2016-09-10)
Text en actes de congrés
Accés obertIn this talk I’ll discuss the DOE/NCI cancer research co-design projects that are a key part of the Presidential Moonshot Cancer Initiative and the brain connectome project at the heart of the National Brain Observatory ... -
Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
(American Chemical Society (ACS), 2018-07-26)
Article
Accés obertIn this research we propose a nanoplatform for anticancer therapy that is based on the combination of three components: (1) an antibiotic to target selectively the mitochondria of cancer cells, inhibiting their functions; ... -
Low-Temperature Heat Capacity Anomalies in Ordered and Disordered Phases of Normal and Deuterated Thiophene
(2021-03-04)
Article
Accés obertWe measured the specific heat Cp of normal (C4H4S) and deuterated (C4D4S) thiophene in the temperature interval of 1 = T, K = 25. C4H4S exhibits a metastable phase II2 and a stable phase V, both with frozen orientational ... -
Machine learning for cancer classification
(Universitat Politècnica de Catalunya, 2018-10)
Projecte Final de Màster Oficial
Accés restringit per decisió de l'autor
Realitzat a/amb: Centre de Regulació Genòmica. Departament de Teoria del Senyal i ComunicacionsIn this thesis, we used support vector machines (SVMs) to build a tissue-of-origin classifier of 17 cancer types. Our classifier, which uses RNA expression data from over 20000 genes, works with high accuracy on primary ... -
Magnetic actuation of multifunctional nanorobotic platforms to induce cancer cell death
(Wiley (John Wiley & Sons), 2018-01-15)
Article
Accés restringit per política de l'editorialSingle-bath potentiostatic-pulsed electrodeposition enables the synthesis of bicomponent (i.e., gold and nickel–nickel oxide) multi-segmented magnetic nanowires that, with extraordinarily low cytotoxicity, are ideal ... -
Mètodes estadístics aplicats a un registre de càncer de base poblacional. Incidència, mortalitat, supervivència i prevalença del càncer de bufeta urinària a Tarragona. 1982-2002.
(Universitat Politècnica de Catalunya, 2009-11)
Projecte/Treball Final de Carrera
Accés obertL'objectiu principal d'aquest treball es exposar quins són i com es calculen els principals indicadors que mesuren l'impacte del càncer en la societat, així com aplicar aquests indicadors per mesurar l'impacte del càncer ... -
Microencapsulation of Doxorubicin using Chitosan
(2023-11-24)
Article
Accés restringit per política de l'editorialIntroduction: For some medical treatments associated with cancer, the invasion of organs is required, which must be done in a totally controlled way to obtain the expected results in the treatment. Today, most medical ... -
Modelo multi-fase para el crecimiento tumoral en la fase avascular neoplásica: una hipótesis quorum sensing en los autoinductores tumorales
(Universitat Politècnica de Catalunya, 2010-11)
Projecte Final de Màster Oficial
Accés obertLos mecanismos bioquímicos y biológicos usados por las células tumorales para actuar como comunidades están basados en procesos de control de crecimiento todavía poco definidos. En este trabajo presentamos la hipótesis ... -
Molecular-assisted solution-based phase transformation of magnetic nanocrystals for hyperthermia
(Universitat Politècnica de Catalunya, 2021-07-05)
Projecte Final de Màster Oficial
Accés obert -
Multi-project and Multi-profile joint Non-negative Matrix Factorization for cancer omic datasets
(Oxford University Press, 2021)
Article
Accés obertAbstract Motivation The integration of multi-omic data using machine learning methods has been focused on solving relevant tasks such as predicting sensitivity to a drug or subtyping patients. Recent integration methods, ... -
Network-guided integration of multi-omics data: towards a comprehensive view of cancer
(Barcelona Supercomputing Center, 2019)
Altres
Accés obert -
On the Characterization of Hepatocellular Carcinoma based on 18F-FDG Kinetics in Early Dynamic PET/CT
(Universitat Politècnica de Catalunya, 2022-07-05)
Treball Final de Grau
Accés obert
Realitzat a/amb: Institut Català d'OncologiaHepatocellular carcinoma (HCC) is the most frequent type of primary hepatic malignant tumor in adults and the third most common cause of cancer-related death worldwide. Its recommended diagnostic techniques are multiphasic ...