Browsing by Author "Mas Moruno, Carlos"
Now showing items 21-40 of 52
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Design and facile solid-phase synthesis of peptide-based LPS-inhibitors containing PEG-like functionalities
(Wiley, 2009)
Article
Restricted access - publisher's policyLPS release from Gram-negative bacteria can result in sepsis, a serious systemic inflammatory response to infection that can lead to septic shock and multiple organ failure. Thus, easy-to-synthesize, effective, and safe ... -
Design of a minimized cyclic tetrapeptide that neutralizes bacterial endotoxins
(2006)
Article
Restricted access - publisher's policySeptic shock is a leading cause of mortality in intensive care patients, and no specific drugs are as yet available for its treatment. Therefore, new leads ar e required in order to increase the numbe r of active ... -
Funcionalización de superfícies anti-fouling sobre titanio para mejora de sus propiedades
(2018-09-01)
Article
Open Access -
Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation
(2017-01-30)
Article
Open Access
Covenantee: Center for Research in NanoEngineering (CRNE) / Deutsches Herzzentrum München / Institut de Bioenginyeria de CatalunyaBiomimetic surface modification with peptides that have specific cell-binding moieties is a promising approach to improve endothelialization of metal-based stents. In this study, we functionalized CoCr surfaces with RGDS, ... -
Functionalizing avß3- or a5ß1-selective integrin antagonists for surface coating: A new tool to discriminate integrin subtypes in vitro
(2013)
Article
Restricted access - publisher's policyThumbnail image of graphical abstract Stuck with the right choice: avß3- or a5ß1-selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured ... -
Immobilization strategies to functionalize tantalum surfaces with cell-adhesive peptides: physicochemical and biological characterization
(Curran, 2014)
Conference lecture
Open Access -
Impedimetric antimicrobial peptide-based sensor for the early detection of periodontopathogenic bacteria
(2016)
Article
Open Access
Covenantee: Center for Research in NanoEngineering (CRNE)Peri-implantitis, an inflammation caused by biofilm formation, constitutes a major cause of implant failure in dentistry. Thus, the detection of bacteria at the early steps of biofilm growth represents a powerful strategy ... -
Increasing avß3 selectivity of the anti-angiogenic drug cilengitide by N-methylation
(2011)
Article
Restricted access - publisher's policyThumbnail image of graphical abstract A subtle change: Structural changes upon amide bond methylation improve the selectivity of the anti-angiogenic drug Cilengitide, which after N-methylation at distinct positions ... -
Installing multifunctionality on titanium with RGD-decorated polymeric nanocapsules: Towards new osteointegrative therapies
(2014)
Conference lecture
Open Access -
Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies
(2015)
Article
Open AccessA novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an ... -
Introducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist.
(2011)
Article
Restricted access - publisher's policyThumbnail image of graphical abstract Tightening the noose: Lasso peptides are a class of stable bacterial peptides with unique characteristics that encourage their application in drug design. Epitope grafting of the ... -
Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium
(2015-04-01)
Article
Open Access
Covenantee: Technische Universität MünchenInteraction between the surface of implants and biological tissues is a key aspect of biomaterials research. Apart from fulfilling the non-toxicity and structural requirements, synthetic materials are asked to direct cell ... -
Multifunctional coatings and nanotopographies: toward cell instructive and antibacterial implants
(2018-11-22)
Article
Restricted access - publisher's policyIn biomaterials science, it is nowadays well accepted that improving the biointegration of dental and orthopedic implants with surrounding tissues is a major goal. However, implant surfaces that support osteointegration ... -
Nanostructure formation enhances the activity of LPS-neutralizing peptides
(2008)
Article
Restricted access - publisher's policyPeptides that interact with lipopolysaccharide (LPS) can provide the basis for the development of new antisepsis agents. In this work, several LPS-neutralizing acyl peptides derived from LALF, BPI, and SAP were prepared, ... -
Novel peptide-based platform for the dual presentation of biologically active peptide motifs on biomaterials
(2014-05-14)
Article
Restricted access - publisher's policyBiofunctionalization of metallic materials with cell adhesive molecules derived from the extracellular matrix is a feasible approach to improve cell-material interactions and enhance the biointegration of implant materials ... -
Novel peptide-based strategies to install osteointegrative properties on metallic biomaterials
(2015)
Conference lecture
Open Access
Covenantee: Technische Universität München -
Pharmacophoric modifications lead to superpotent avß3 integrin ligands with suppressed a5ß1 activity
(2014-04-24)
Article
Restricted access - publisher's policy
Covenantee: Technische Universität MünchenThe selective targeting of the avß3 integrin subtype without affecting the structurally closely related receptor a5ß1 is crucial for understanding the details of their biological and pathological functions and thus of great ... -
Polymer-free immobilization of a cyclic RGD peptide on a nitinol stent promotes integrin-dependent endothelial coverage of strut surfaces
(2012)
Article
Restricted access - publisher's policy
Covenantee: Technische Universität München / CVPath InstituteThis study examined the utility of a stabilized cyclic RGD peptide chemically modified to selectively bind to titanium-oxide for enhanced biocompatibility of self-expanding nitinol stents. Endothelial cells express integrin ... -
Reducció de l’adhesió i formació de biofilm bacterià sobre titani mitjançant immobilització d’un pèptid antibacterià
(EUETIB, 2014-12-01)
Conference report
Open AccessL’ús d’implants de titani per a traumatologia i odontologia és una pràctica molt estesa actualment. El seu èxit, però, es veu afectat pels casos de infeccions que pateixen. En el cas concret dels implants dentals, el 14% ... -
Regenerating bone via multifunctional coatings: the blending of cell integration and bacterial inhibition properties on the surface of biomaterials
(2017-07-05)
Article
Restricted access - publisher's policyIn dentistry and orthopedics, it is well accepted that implant fixation is a major goal. However, an emerging concern is bacterial infection. Infection of metallic implants can be catastrophic and significantly reduce ...
